Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 832235..832889 Replicon chromosome
Accession NZ_CP099298
Organism Citrobacter freundii strain RHB02-E3-C01

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag NFJ20_RS04030 Protein ID WP_003026936.1
Coordinates 832482..832889 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag NFJ20_RS04025 Protein ID WP_003026938.1
Coordinates 832235..832501 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ20_RS04000 (827435) 827435..828868 - 1434 WP_279274273.1 6-phospho-beta-glucosidase BglA -
NFJ20_RS04005 (828990) 828990..829718 - 729 WP_279274511.1 MurR/RpiR family transcriptional regulator -
NFJ20_RS04010 (829771) 829771..830082 + 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
NFJ20_RS04015 (830245) 830245..830904 + 660 WP_003838267.1 hemolysin III family protein -
NFJ20_RS04020 (830998) 830998..831978 - 981 WP_003026944.1 tRNA-modifying protein YgfZ -
NFJ20_RS04025 (832235) 832235..832501 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
NFJ20_RS04030 (832482) 832482..832889 + 408 WP_003026936.1 protein YgfX Toxin
NFJ20_RS04035 (832934) 832934..833455 - 522 WP_003026933.1 flavodoxin FldB -
NFJ20_RS04040 (833570) 833570..834466 + 897 WP_279274274.1 site-specific tyrosine recombinase XerD -
NFJ20_RS04045 (834490) 834490..835203 + 714 WP_279274275.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFJ20_RS04050 (835209) 835209..836942 + 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T248320 WP_003026936.1 NZ_CP099298:832482-832889 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT248320 WP_003026938.1 NZ_CP099298:832235-832501 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References