Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 272617..273248 Replicon chromosome
Accession NZ_CP099298
Organism Citrobacter freundii strain RHB02-E3-C01

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag NFJ20_RS01265 Protein ID WP_003837806.1
Coordinates 272617..272892 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag NFJ20_RS01270 Protein ID WP_003837808.1
Coordinates 272889..273248 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ20_RS01255 (268668) 268668..271415 + 2748 WP_279274198.1 ribosome-associated ATPase/putative transporter RbbA -
NFJ20_RS01260 (271415) 271415..272539 + 1125 WP_003837801.1 ABC transporter permease -
NFJ20_RS01265 (272617) 272617..272892 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
NFJ20_RS01270 (272889) 272889..273248 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFJ20_RS01275 (273361) 273361..273762 - 402 WP_032937232.1 nickel-responsive transcriptional regulator NikR -
NFJ20_RS01280 (273812) 273812..274390 - 579 WP_003023390.1 4'-phosphopantetheinyl transferase AcpT -
NFJ20_RS01285 (274453) 274453..275502 - 1050 WP_003023393.1 AI-2E family transporter -
NFJ20_RS01290 (275636) 275636..276853 + 1218 WP_016151126.1 MFS transporter -
NFJ20_RS01295 (276857) 276857..277414 - 558 WP_003837816.1 DcrB family lipoprotein -
NFJ20_RS01300 (277487) 277487..278152 - 666 WP_003023401.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T248317 WP_003837806.1 NZ_CP099298:272617-272892 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT248317 WP_003837808.1 NZ_CP099298:272889-273248 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References