Detailed information of TA system TA024830

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 246577..247238
• Replicon: chromosome
• Accession: NC_014311
• Organism: Ralstonia solanacearum PSI07

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: RPSI07_RS09065
• Protein ID: WP_013211023.1
• Coordinates: 246577..246990 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q8Y121
• Locus tag: RPSI07_RS09070
• Protein ID: WP_011000825.1
• Coordinates: 246987..247238 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RPSI07_RS09035	242189..242578	+	390	WP_013211018.1	hypothetical protein	-
RPSI07_RS09040	242575..242796	+	222	WP_013211019.1	hypothetical protein	-
RPSI07_RS09045	242771..243415	+	645	WP_048817288.1	hypothetical protein	-
RPSI07_RS09050	243458..243748	-	291	WP_013211021.1	H-NS histone family protein	-
RPSI07_RS09055	244312..245370	+	1059	WP_013211022.1	phosphoadenosine phosphosulfate reductase family protein	-
RPSI07_RS24875	245378..246505	+	1128	WP_082320177.1	DNA cytosine methyltransferase	-
RPSI07_RS09065	246577..246990	-	414	WP_013211023.1	type II toxin-antitoxin system VapC family toxin	Toxin
RPSI07_RS09070	246987..247238	-	252	WP_011000825.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
RPSI07_RS09075	247318..251418	+	4101	WP_013211024.1	phage tail tape measure protein	-
RPSI07_RS09080	251424..251819	+	396	WP_013211025.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	204413..263587	59174

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15605.94 Da
• Isoelectric Point: 5.7557

>T24830 WP_013211023.1 NC_014311:c246990-246577 [Ralstonia solanacearum PSI07]
MSYLIDTNVLSELRRKAPDARVVAWMQDRPRQSLYLSVLTLGEIRKGIERLEDAVRRQNLIDWLEVELPNYFLGRLLDID
AHTADRWGRLMSSAGRPLPAIDGLLAATALQHDLTLVTRNTKDFAGLDVQLINPWEA

Nucleotide

• Length: 414 bp

>T24830 NC_014311:c246990-246577 [Ralstonia solanacearum PSI07]
TTGAGTTACCTGATCGACACCAATGTCCTGTCCGAATTGCGTCGCAAAGCGCCCGATGCGCGCGTGGTGGCCTGGATGCA
GGACCGCCCGCGCCAGTCGCTCTACCTGAGCGTGCTGACCCTGGGCGAGATTCGCAAAGGTATCGAGCGGCTGGAGGACG
CGGTACGCCGCCAGAACCTGATTGACTGGCTCGAAGTGGAATTGCCGAACTACTTTCTCGGCCGATTGCTCGACATCGAT
GCACATACTGCGGACCGCTGGGGCCGGCTGATGTCCTCGGCTGGCCGCCCCCTGCCCGCCATCGACGGCCTGCTGGCCGC
GACCGCCCTGCAACACGACCTCACGCTGGTCACGCGCAACACCAAAGATTTCGCGGGGCTCGACGTCCAGCTCATCAACC
CCTGGGAAGCCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9335.52 Da
• Isoelectric Point: 5.0774

>AT24830 WP_011000825.1 NC_014311:c247238-246987 [Ralstonia solanacearum PSI07]
MQSWQMQAAKARFSDVVKRAADDGPQEITVHGRPVAVVISRALFDRLSGSGESLVSFMRQSPLADQDDVVFERERSLPRE
VEF

Nucleotide

• Length: 252 bp

>AT24830 NC_014311:c247238-246987 [Ralstonia solanacearum PSI07]
ATGCAAAGCTGGCAAATGCAGGCCGCCAAGGCGCGGTTTTCCGATGTCGTGAAGCGGGCAGCAGACGACGGCCCGCAGGA
AATCACCGTGCATGGCCGCCCGGTGGCGGTAGTGATCTCGCGCGCACTGTTCGATCGCTTGAGCGGCAGCGGTGAGTCGC
TGGTCAGCTTCATGCGCCAATCCCCGCTGGCCGATCAGGACGATGTCGTTTTTGAGCGCGAGCGCAGCCTGCCGCGCGAG
GTCGAGTTTTGA

Structures

Antitoxin

• AlphaFold DB: Q8Y121