248299

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4677980..4678683 Replicon chromosome
Accession NZ_CP099260
Organism Klebsiella aerogenes strain RHB08-SO-C04

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag NFJ54_RS22865 Protein ID WP_279281273.1
Coordinates 4677980..4678321 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag NFJ54_RS22870 Protein ID WP_050131139.1
Coordinates 4678342..4678683 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ54_RS22835 (NFJ54_22805) 4673338..4673664 + 327 WP_213315606.1 hypothetical protein -
NFJ54_RS22840 (NFJ54_22810) 4673702..4674337 - 636 WP_086630702.1 HNH endonuclease -
NFJ54_RS22845 (NFJ54_22815) 4674517..4675386 + 870 WP_086630701.1 HNH endonuclease -
NFJ54_RS22850 (NFJ54_22820) 4675422..4675763 - 342 WP_116289501.1 hypothetical protein -
NFJ54_RS22855 (NFJ54_22825) 4675760..4676077 - 318 WP_226938505.1 type IV secretion protein Rhs -
NFJ54_RS22860 (NFJ54_22830) 4676709..4677716 - 1008 WP_196010439.1 restriction endonuclease -
NFJ54_RS22865 (NFJ54_22835) 4677980..4678321 - 342 WP_279281273.1 TA system toxin CbtA family protein Toxin
NFJ54_RS22870 (NFJ54_22840) 4678342..4678683 - 342 WP_050131139.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NFJ54_RS22875 (NFJ54_22845) 4678694..4679236 - 543 WP_017880113.1 DNA repair protein RadC -
NFJ54_RS22880 (NFJ54_22850) 4679249..4679689 - 441 WP_196010437.1 antirestriction protein -
NFJ54_RS22885 (NFJ54_22855) 4679720..4680541 - 822 WP_196010436.1 DUF932 domain-containing protein -
NFJ54_RS22890 (NFJ54_22860) 4680662..4681135 - 474 WP_196010435.1 hypothetical protein -
NFJ54_RS22895 (NFJ54_22865) 4681206..4681658 - 453 WP_196010434.1 hypothetical protein -
NFJ54_RS22900 (NFJ54_22870) 4681694..4682410 - 717 WP_057775073.1 WYL domain-containing protein -
NFJ54_RS22905 (NFJ54_22875) 4682654..4683529 - 876 WP_196010433.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4671839..4693561 21722


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-111)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12855.77 Da        Isoelectric Point: 8.4941

>T248299 WP_279281273.1 NZ_CP099260:c4678321-4677980 [Klebsiella aerogenes]
MKTLPATNPQAATLYLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLARIDFRRF
DWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12821.45 Da        Isoelectric Point: 6.3148

>AT248299 WP_050131139.1 NZ_CP099260:c4678683-4678342 [Klebsiella aerogenes]
MKSTDSENDSFLKWGLNCNMTPCFGARLVQEGNRLHYLADRACITGEFSNAESLKLDEVFTRFIRQMESMLTTGEMNPRH
AHSVTLYHNGFTCEADTLGSCGYVYIAVYPTHR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References