Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4660807..4661617 Replicon chromosome
Accession NZ_CP099260
Organism Klebsiella aerogenes strain RHB08-SO-C04

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag NFJ54_RS22775 Protein ID WP_063444594.1
Coordinates 4660807..4661340 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NFJ54_RS22780 Protein ID WP_002887278.1
Coordinates 4661351..4661617 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ54_RS22770 (NFJ54_22740) 4659639..4660760 + 1122 WP_015704249.1 cupin domain-containing protein -
NFJ54_RS22775 (NFJ54_22745) 4660807..4661340 - 534 WP_063444594.1 type II toxin-antitoxin system toxin KacT Toxin
NFJ54_RS22780 (NFJ54_22750) 4661351..4661617 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NFJ54_RS22785 (NFJ54_22755) 4661696..4663153 - 1458 WP_086557054.1 Cu(+)/Ag(+) sensor histidine kinase -
NFJ54_RS22790 (NFJ54_22760) 4663143..4663826 - 684 WP_008807068.1 copper response regulator transcription factor CusR -
NFJ54_RS22795 (NFJ54_22765) 4664000..4665385 + 1386 WP_227393476.1 efflux transporter outer membrane subunit -
NFJ54_RS22800 (NFJ54_22770) 4665403..4665747 + 345 WP_042894147.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19883.80 Da        Isoelectric Point: 5.0044

>T248298 WP_063444594.1 NZ_CP099260:c4661340-4660807 [Klebsiella aerogenes]
MDQLLTIEMIADEFRYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPMLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT248298 WP_002887278.1 NZ_CP099260:c4661617-4661351 [Klebsiella aerogenes]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References