248295

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2618401..2619140 Replicon chromosome
Accession NZ_CP099260
Organism Klebsiella aerogenes strain RHB08-SO-C04

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag NFJ54_RS12785 Protein ID WP_279281548.1
Coordinates 2618655..2619140 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag NFJ54_RS12780 Protein ID WP_015705366.1
Coordinates 2618401..2618667 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ54_RS12755 (NFJ54_12735) 2613736..2614323 + 588 WP_100279812.1 hypothetical protein -
NFJ54_RS12760 (NFJ54_12740) 2614320..2615639 + 1320 WP_279281547.1 ATP-binding protein -
NFJ54_RS12765 (NFJ54_12745) 2615639..2616256 + 618 WP_045360840.1 response regulator -
NFJ54_RS12770 (NFJ54_12750) 2616352..2616849 + 498 WP_015705368.1 heme-binding protein -
NFJ54_RS12775 (NFJ54_12755) 2616893..2618128 - 1236 WP_020078885.1 MFS transporter -
NFJ54_RS12780 (NFJ54_12760) 2618401..2618667 + 267 WP_015705366.1 DUF1778 domain-containing protein Antitoxin
NFJ54_RS12785 (NFJ54_12765) 2618655..2619140 + 486 WP_279281548.1 GNAT family N-acetyltransferase Toxin
NFJ54_RS12790 (NFJ54_12770) 2619212..2620828 + 1617 WP_032711617.1 FAD-NAD(P)-binding protein -
NFJ54_RS12795 (NFJ54_12775) 2620947..2622047 + 1101 WP_015705363.1 NADH:flavin oxidoreductase/NADH oxidase -
NFJ54_RS12800 (NFJ54_12780) 2622104..2622262 - 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
NFJ54_RS12805 (NFJ54_12785) 2622523..2623593 + 1071 WP_015705361.1 mannonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17633.28 Da        Isoelectric Point: 8.8590

>T248295 WP_279281548.1 NZ_CP099260:2618655-2619140 [Klebsiella aerogenes]
MGKISAPTPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHTEATGGLRRNM
PDPIPVIILARLAIDCAYHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT248295 WP_015705366.1 NZ_CP099260:2618401-2618667 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FSM9

References