Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 839082..839739 Replicon chromosome
Accession NZ_CP099260
Organism Klebsiella aerogenes strain RHB08-SO-C04

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag NFJ54_RS04095 Protein ID WP_015369792.1
Coordinates 839329..839739 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag NFJ54_RS04090 Protein ID WP_015369791.1
Coordinates 839082..839348 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ54_RS04065 (NFJ54_04065) 834257..835690 - 1434 WP_015369787.1 6-phospho-beta-glucosidase BglA -
NFJ54_RS04070 (NFJ54_04070) 835810..836538 - 729 WP_015369788.1 MurR/RpiR family transcriptional regulator -
NFJ54_RS04075 (NFJ54_04075) 836589..836900 + 312 WP_015703422.1 N(4)-acetylcytidine aminohydrolase -
NFJ54_RS04080 (NFJ54_04080) 837065..837724 + 660 WP_008806429.1 hemolysin III family protein -
NFJ54_RS04085 (NFJ54_04085) 837875..838858 - 984 WP_015369790.1 tRNA-modifying protein YgfZ -
NFJ54_RS04090 (NFJ54_04090) 839082..839348 + 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
NFJ54_RS04095 (NFJ54_04095) 839329..839739 + 411 WP_015369792.1 protein YgfX Toxin
NFJ54_RS04100 (NFJ54_04100) 839747..840268 - 522 WP_015369793.1 flavodoxin FldB -
NFJ54_RS04105 (NFJ54_04105) 840369..841265 + 897 WP_279281364.1 site-specific tyrosine recombinase XerD -
NFJ54_RS04110 (NFJ54_04110) 841288..842001 + 714 WP_234276462.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFJ54_RS04115 (NFJ54_04115) 842007..843740 + 1734 WP_126027612.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T248290 WP_015369792.1 NZ_CP099260:839329-839739 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT248290 WP_015369791.1 NZ_CP099260:839082-839348 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References