Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1574905..1576522 Replicon plasmid mpPSI07
Accession NC_014310
Organism Ralstonia solanacearum PSI07

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag RPSI07_RS05775 Protein ID WP_013210322.1
Coordinates 1575176..1576522 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag RPSI07_RS05770 Protein ID WP_013210321.1
Coordinates 1574905..1575171 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RPSI07_RS05740 1570156..1570632 + 477 WP_013210315.1 RidA family protein -
RPSI07_RS05745 1570735..1571574 + 840 WP_013210316.1 AraC family transcriptional regulator -
RPSI07_RS05750 1571577..1572695 + 1119 WP_013210317.1 hypothetical protein -
RPSI07_RS05755 1572722..1573105 - 384 WP_013210318.1 VOC family protein -
RPSI07_RS05760 1573345..1573788 + 444 WP_013210319.1 PGDYG domain-containing protein -
RPSI07_RS05765 1573804..1574709 - 906 WP_048817081.1 hypothetical protein -
RPSI07_RS05770 1574905..1575171 + 267 WP_013210321.1 helix-turn-helix domain-containing protein Antitoxin
RPSI07_RS05775 1575176..1576522 + 1347 WP_013210322.1 type II toxin-antitoxin system HipA family toxin Toxin
RPSI07_RS05780 1576599..1577495 + 897 WP_013210323.1 DUF2236 domain-containing protein -
RPSI07_RS05785 1577499..1579067 - 1569 WP_048817082.1 MFS transporter -
RPSI07_RS05790 1579160..1580110 - 951 WP_013210325.1 LysR family transcriptional regulator -
RPSI07_RS05795 1580250..1580876 + 627 WP_013210326.1 FMN-dependent NADH-azoreductase -
RPSI07_RS25940 1581010..1581156 - 147 WP_162899024.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / cyaB / flgC / flgG / fliM / fliI / acrB / adeG / cheY / cheB / cheW / motA 1..2085000 2085000


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 49874.19 Da        Isoelectric Point: 7.8445

>T24829 WP_013210322.1 NC_014310:1575176-1576522 [Ralstonia solanacearum PSI07]
MGRRSHTRALGLWMNGTHVGHWELHPHQGDVLKYAASWVAAPEGRPLSLSLPFTPDNAPYKGPAVRAYFENLLPDSRDIR
ERIARRFQAGTTEAFDLLEQIGRDCIGALQVLPADMAPASIGDIDAEPLTEAQIAQTLRETVAPPPLGGMPEDDGNFRIS
IAGAQEKTAFLQIDERWYRPRGATPTSHIFKLPMGRVGNMKLDLSESVENEWLCSLVLRAYGLPIAHCQPLVFEDQKVLA
VERFDRMWRDHRGRQLIRLPQEDMCQATATPPHLKYEADGGPGIDRIMGLLDGSARRDADRLMLFQSQVLFWMLCAPDGH
AKNFSLALRPGGAYALTPLYDVMSAYPLLGEGPGKLSPHRIRLAMAVRSKNPHWKMQDVQRRHWLGLGQRHGIVTPEGGH
AAAIVDSLVARTPEVIRTVRARLPEDFPQPLADRILRGLQSAADRLAQ

Download         Length: 1347 bp

>T24829 NC_014310:1575176-1576522 [Ralstonia solanacearum PSI07]
ATGGGGCGCCGGTCGCATACGCGGGCCCTCGGGCTCTGGATGAATGGCACCCATGTCGGCCACTGGGAGCTGCACCCGCA
TCAAGGCGATGTGCTGAAGTACGCGGCGTCCTGGGTGGCCGCACCCGAGGGGCGGCCCTTGTCGCTATCCCTGCCCTTCA
CGCCGGACAACGCGCCGTACAAAGGCCCGGCGGTCCGGGCATATTTCGAAAACCTCCTGCCGGACAGCCGCGACATCCGC
GAGCGCATCGCGCGCCGGTTCCAGGCGGGCACGACCGAGGCATTCGACCTGCTGGAGCAGATCGGCCGCGACTGCATCGG
CGCCCTGCAGGTACTGCCCGCCGACATGGCCCCAGCCAGCATCGGCGACATCGACGCGGAGCCGCTGACCGAGGCGCAGA
TCGCGCAGACGCTGCGGGAGACGGTCGCCCCGCCGCCCCTGGGCGGCATGCCGGAGGACGACGGCAATTTCCGCATCTCG
ATTGCCGGCGCGCAGGAAAAGACCGCCTTCCTCCAGATCGACGAACGCTGGTACCGCCCCCGGGGCGCGACGCCGACCAG
CCACATCTTCAAGCTGCCGATGGGGCGGGTCGGCAACATGAAGCTGGACCTGAGCGAGTCGGTGGAAAACGAATGGCTGT
GCTCCCTGGTGCTGCGGGCGTATGGGCTGCCCATCGCCCACTGCCAGCCACTGGTGTTCGAAGACCAGAAAGTCCTGGCC
GTGGAACGGTTCGACCGCATGTGGCGGGACCACCGCGGCAGGCAGCTCATCCGCCTGCCGCAGGAAGACATGTGCCAGGC
GACGGCCACGCCCCCGCACCTGAAGTACGAGGCCGACGGCGGCCCCGGCATCGACCGCATCATGGGCCTGCTCGACGGCT
CCGCGCGCCGGGATGCCGACCGCCTGATGCTGTTCCAGAGCCAGGTGCTGTTCTGGATGCTGTGCGCGCCCGACGGCCAT
GCGAAGAACTTCAGCCTCGCGCTTCGCCCCGGCGGCGCCTACGCGCTCACGCCGCTGTACGACGTGATGTCGGCCTACCC
GCTGCTGGGCGAGGGGCCGGGCAAGCTCTCACCGCACCGGATCCGGCTGGCAATGGCCGTCCGCTCGAAGAACCCGCACT
GGAAAATGCAAGACGTCCAGCGGCGCCACTGGCTGGGCCTGGGCCAGCGGCATGGCATCGTCACGCCCGAGGGCGGGCAT
GCGGCCGCCATCGTGGACAGTCTGGTCGCCCGGACCCCCGAGGTGATCCGCACCGTGCGCGCGCGGCTGCCGGAAGACTT
CCCGCAGCCGCTGGCCGACCGCATTCTGCGGGGGCTGCAGAGCGCCGCGGACAGGCTCGCGCAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9743.27 Da        Isoelectric Point: 11.3495

>AT24829 WP_013210321.1 NC_014310:1574905-1575171 [Ralstonia solanacearum PSI07]
MNEFIVRTPEQLPAILKGFRKQAGLSQAELAARMGMRQQTLSALERNAENVSAGRLMRLLSVLGVELVLRKPDASGERGR
PASDQPQW

Download         Length: 267 bp

>AT24829 NC_014310:1574905-1575171 [Ralstonia solanacearum PSI07]
ATGAACGAGTTCATCGTACGCACCCCCGAGCAGTTGCCGGCGATTCTCAAGGGCTTCCGCAAACAGGCCGGGCTGAGCCA
GGCTGAACTGGCCGCCCGGATGGGCATGCGCCAGCAAACCCTCTCCGCACTGGAGCGCAACGCAGAAAACGTGAGCGCCG
GACGGCTGATGCGCCTGTTGTCGGTGCTGGGCGTCGAGCTGGTGCTGCGCAAACCCGACGCCTCCGGCGAGCGCGGCCGC
CCGGCATCCGACCAGCCGCAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References