248288

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 264281..264912 Replicon chromosome
Accession NZ_CP099260
Organism Klebsiella aerogenes strain RHB08-SO-C04

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H3FL31
Locus tag NFJ54_RS01205 Protein ID WP_015703741.1
Coordinates 264281..264556 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H3FNK6
Locus tag NFJ54_RS01210 Protein ID WP_015703740.1
Coordinates 264553..264912 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ54_RS01185 (NFJ54_01185) 259510..259845 + 336 WP_015703743.1 universal stress protein UspB -
NFJ54_RS01190 (NFJ54_01190) 259910..261406 - 1497 WP_015369272.1 inorganic phosphate transporter PitA -
NFJ54_RS01195 (NFJ54_01195) 261637..262830 + 1194 WP_048229922.1 NAD(P)/FAD-dependent oxidoreductase -
NFJ54_RS01200 (NFJ54_01200) 262871..263884 - 1014 WP_015369274.1 magnesium transporter -
NFJ54_RS01205 (NFJ54_01205) 264281..264556 + 276 WP_015703741.1 type II toxin-antitoxin system HicA family toxin Toxin
NFJ54_RS01210 (NFJ54_01210) 264553..264912 + 360 WP_015703740.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFJ54_RS01215 (NFJ54_01215) 264940..265341 - 402 WP_020077744.1 nickel-responsive transcriptional regulator NikR -
NFJ54_RS01220 (NFJ54_01220) 265329..266120 - 792 WP_032715259.1 nickel import ATP-binding protein NikE -
NFJ54_RS01225 (NFJ54_01225) 266117..266881 - 765 WP_015369277.1 nickel import ATP-binding protein NikD -
NFJ54_RS01230 (NFJ54_01230) 266881..267714 - 834 WP_279281327.1 nickel ABC transporter permease subunit NikC -
NFJ54_RS01235 (NFJ54_01235) 267711..268655 - 945 WP_045413435.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10258.89 Da        Isoelectric Point: 10.4888

>T248288 WP_015703741.1 NZ_CP099260:264281-264556 [Klebsiella aerogenes]
MEQQVLSLRKKQRNTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13305.02 Da        Isoelectric Point: 4.3472

>AT248288 WP_015703740.1 NZ_CP099260:264553-264912 [Klebsiella aerogenes]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCREAGIEPYAQPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FL31

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FNK6

References