248287

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 76657..77678 Replicon chromosome
Accession NZ_CP099260
Organism Klebsiella aerogenes strain RHB08-SO-C04

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A0G9UXE3
Locus tag NFJ54_RS00395 Protein ID WP_032706547.1
Coordinates 77103..77678 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag NFJ54_RS00390 Protein ID WP_279281318.1
Coordinates 76657..77103 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ54_RS00365 (NFJ54_00365) 72178..72957 + 780 WP_058676322.1 MBL fold metallo-hydrolase -
NFJ54_RS00370 (NFJ54_00370) 72979..73932 + 954 WP_058676358.1 helix-turn-helix domain-containing protein -
NFJ54_RS00375 (NFJ54_00375) 73929..74978 - 1050 WP_279281317.1 NAD(P)-dependent alcohol dehydrogenase -
NFJ54_RS00380 (NFJ54_00380) 75136..75438 - 303 WP_045390549.1 putative quinol monooxygenase -
NFJ54_RS00385 (NFJ54_00385) 75439..76446 - 1008 WP_042893659.1 zinc-binding alcohol dehydrogenase family protein -
NFJ54_RS00390 (NFJ54_00390) 76657..77103 + 447 WP_279281318.1 helix-turn-helix domain-containing protein Antitoxin
NFJ54_RS00395 (NFJ54_00395) 77103..77678 + 576 WP_032706547.1 PIN domain-containing protein Toxin
NFJ54_RS00400 (NFJ54_00400) 77983..79179 + 1197 WP_042893658.1 hypothetical protein -
NFJ54_RS00405 (NFJ54_00405) 79462..80499 - 1038 WP_045411414.1 virulence RhuM family protein -
NFJ54_RS00410 (NFJ54_00410) 80734..81022 - 289 Protein_81 SymE family type I addiction module toxin -
NFJ54_RS00415 (NFJ54_00415) 81094..81396 - 303 WP_020077664.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-115)

Antitoxin

SinI-like, DNA-binding domain

(79-126)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21688.29 Da        Isoelectric Point: 6.2900

>T248287 WP_032706547.1 NZ_CP099260:77103-77678 [Klebsiella aerogenes]
MRHSPYPVILDACVLYPARLRDLLMHLGIAGLYQPKWSRFIHDEWCRNLLINRPDIAPEALRRTVDLMNAALPDANVTGF
AGLINGLVLPDPDDRHVLAAAIRAKAEIIVTLNHKDFPAESLLPFEIETLHPDVFISDLFDLNHALALEAVRRQRQSLKH
PPMTVDEFLEMLLKQGLPMTVKELANYQYAI

Download         Length: 576 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16697.33 Da        Isoelectric Point: 7.0630

>AT248287 WP_279281318.1 NZ_CP099260:76657-77103 [Klebsiella aerogenes]
MTKLNLPNPLESELAQRGQRELAAYLSTHLKTQRIAIVGEDDKTHTIELPTSALTMLMEILGELACGNAVQIVPVHAELT
TQEAANILNVSRPHMVKLLEARKLPFHKTGRHRRVLFADLMEYKKRREQESLDAMQALADQAQDLGMY

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G9UXE3

Antitoxin

Source ID Structure

References