Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 53380..53930 Replicon chromosome
Accession NZ_CP099260
Organism Klebsiella aerogenes strain RHB08-SO-C04

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag NFJ54_RS00270 Protein ID WP_047078232.1
Coordinates 53380..53694 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag NFJ54_RS00275 Protein ID WP_045390507.1
Coordinates 53697..53930 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ54_RS00250 (NFJ54_00250) 48812..50191 - 1380 WP_020077645.1 carbohydrate porin -
NFJ54_RS00255 (NFJ54_00255) 50469..51794 - 1326 WP_015703869.1 PTS cellobiose transporter subunit IIC -
NFJ54_RS00260 (NFJ54_00260) 51806..52120 - 315 WP_015369080.1 PTS sugar transporter subunit IIB -
NFJ54_RS00265 (NFJ54_00265) 52415..53350 + 936 WP_032709465.1 LacI family DNA-binding transcriptional regulator -
NFJ54_RS00270 (NFJ54_00270) 53380..53694 - 315 WP_047078232.1 CcdB family protein Toxin
NFJ54_RS00275 (NFJ54_00275) 53697..53930 - 234 WP_045390507.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
NFJ54_RS00280 (NFJ54_00280) 54147..54437 - 291 WP_015369086.1 YicS family protein -
NFJ54_RS00285 (NFJ54_00285) 54539..55441 - 903 WP_279281315.1 EamA family transporter -
NFJ54_RS00290 (NFJ54_00290) 55505..56410 - 906 WP_049034791.1 AraC family transcriptional regulator -
NFJ54_RS00295 (NFJ54_00295) 56527..57064 + 538 Protein_58 peroxidase-related enzyme -
NFJ54_RS00300 (NFJ54_00300) 57084..57554 - 471 WP_015369090.1 nuclear transport factor 2 family protein -
NFJ54_RS00305 (NFJ54_00305) 57554..58183 - 630 WP_015369091.1 pyridoxamine 5'-phosphate oxidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11416.37 Da        Isoelectric Point: 6.9740

>T248286 WP_047078232.1 NZ_CP099260:c53694-53380 [Klebsiella aerogenes]
VQYYVYRSTSKNPAFPLLIDVTSDIIGDINRRLAIPLMPVERLGVNPAPERLNPILALVDGKKYVLMTHEAATIPVKALG
VEFCDASGYRNAIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8498.63 Da        Isoelectric Point: 6.9795

>AT248286 WP_045390507.1 NZ_CP099260:c53930-53697 [Klebsiella aerogenes]
MTVKRKTQNVTVTLERDLLNRAREAGVNMSATLAAALDAELKKHAALRWREANAEAIAAMNALGEETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References