248283

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4174714..4175290 Replicon chromosome
Accession NZ_CP099254
Organism Citrobacter freundii strain RHB09-E3-C07

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag NFJ59_RS19735 Protein ID WP_117342369.1
Coordinates 4175003..4175290 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag NFJ59_RS19730 Protein ID WP_117342368.1
Coordinates 4174714..4175016 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ59_RS19715 (4171173) 4171173..4173323 + 2151 WP_135912629.1 pyruvate/proton symporter BtsT -
NFJ59_RS19720 (4173440) 4173440..4173634 + 195 WP_003830038.1 YbdD/YjiX family protein -
NFJ59_RS19725 (4173647) 4173647..4174603 + 957 WP_096758431.1 GTPase -
NFJ59_RS19730 (4174714) 4174714..4175016 - 303 WP_117342368.1 BrnA antitoxin family protein Antitoxin
NFJ59_RS19735 (4175003) 4175003..4175290 - 288 WP_117342369.1 BrnT family toxin Toxin
NFJ59_RS19740 (4175463) 4175463..4175627 - 165 WP_279277307.1 DUF1127 domain-containing protein -
NFJ59_RS19745 (4175804) 4175804..4177216 + 1413 WP_279277308.1 PLP-dependent aminotransferase family protein -
NFJ59_RS19750 (4177243) 4177243..4177908 - 666 Protein_3866 Rpn family recombination-promoting nuclease/putative transposase -
NFJ59_RS19755 (4178345) 4178345..4179586 + 1242 WP_279277309.1 multidrug efflux MFS transporter MdtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(42-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11362.75 Da        Isoelectric Point: 7.5239

>T248283 WP_117342369.1 NZ_CP099254:c4175290-4175003 [Citrobacter freundii]
MPMEFEWDANKAQSNHRKHGVRFEDAVLVFDDPRHLSRQDRYENGEYRWQTIGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHD

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11444.95 Da        Isoelectric Point: 8.5366

>AT248283 WP_117342368.1 NZ_CP099254:c4175016-4174714 [Citrobacter freundii]
MSMIKHKRGSASALSAQHEAELKALANKPDDDIDYSDIPVTEDEQWSEANRGTFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References