Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3650122..3650742 Replicon chromosome
Accession NZ_CP099254
Organism Citrobacter freundii strain RHB09-E3-C07

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFJ59_RS17410 Protein ID WP_002892050.1
Coordinates 3650524..3650742 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag NFJ59_RS17405 Protein ID WP_115259201.1
Coordinates 3650122..3650496 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ59_RS17395 (3645268) 3645268..3646461 + 1194 WP_096758038.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFJ59_RS17400 (3646484) 3646484..3649633 + 3150 WP_096758039.1 efflux RND transporter permease AcrB -
NFJ59_RS17405 (3650122) 3650122..3650496 + 375 WP_115259201.1 Hha toxicity modulator TomB Antitoxin
NFJ59_RS17410 (3650524) 3650524..3650742 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFJ59_RS17415 (3651124) 3651124..3651597 + 474 WP_181618814.1 YlaC family protein -
NFJ59_RS17420 (3651671) 3651671..3651811 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFJ59_RS17425 (3651813) 3651813..3652073 - 261 WP_115259215.1 type B 50S ribosomal protein L31 -
NFJ59_RS17430 (3652258) 3652258..3653811 + 1554 WP_181618813.1 EAL domain-containing protein -
NFJ59_RS17435 (3653865) 3653865..3654218 - 354 WP_115259217.1 DUF1428 family protein -
NFJ59_RS17440 (3654301) 3654301..3654912 - 612 WP_115259218.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248282 WP_002892050.1 NZ_CP099254:3650524-3650742 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14454.26 Da        Isoelectric Point: 5.5653

>AT248282 WP_115259201.1 NZ_CP099254:3650122-3650496 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSNYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure

References