Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2462334..2463103 Replicon chromosome
Accession NZ_CP099254
Organism Citrobacter freundii strain RHB09-E3-C07

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag NFJ59_RS11665 Protein ID WP_279276842.1
Coordinates 2462621..2463103 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag NFJ59_RS11660 Protein ID WP_168246960.1
Coordinates 2462334..2462630 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ59_RS11645 (2458674) 2458674..2459303 + 630 WP_181619409.1 winged helix-turn-helix transcriptional regulator -
NFJ59_RS11650 (2459413) 2459413..2460030 + 618 WP_181619408.1 outer membrane beta-barrel protein -
NFJ59_RS11655 (2460239) 2460239..2462221 + 1983 WP_279276841.1 alkyl sulfatase dimerization domain-containing protein -
NFJ59_RS11660 (2462334) 2462334..2462630 + 297 WP_168246960.1 DUF1778 domain-containing protein Antitoxin
NFJ59_RS11665 (2462621) 2462621..2463103 + 483 WP_279276842.1 GNAT family N-acetyltransferase Toxin
NFJ59_RS11670 (2463113) 2463113..2463419 - 307 Protein_2288 NAD(P)H-binding protein -
NFJ59_RS11675 (2463568) 2463568..2464461 + 894 WP_279276843.1 LysR family transcriptional regulator -
NFJ59_RS11680 (2464486) 2464486..2465474 - 989 Protein_2290 aldo/keto reductase -
NFJ59_RS11685 (2465498) 2465498..2466349 - 852 WP_279276844.1 aldo/keto reductase -
NFJ59_RS11690 (2466629) 2466629..2467501 + 873 WP_279276845.1 aldo/keto reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(29-148)

Antitoxin

Vibrio phage ICP1, Orf50

(17-91)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17702.31 Da        Isoelectric Point: 7.2887

>T248281 WP_279276842.1 NZ_CP099254:2462621-2463103 [Citrobacter freundii]
MEINVTAPALLTEGHELQPFDCGNEVLNDWLCRRAIKNQYINASRTFVICLESTQRVVGYYSIATGSVSHADLGRSLRQN
MPDPVPVVLLGRLAVDASTQGHSFGKWLLNDAVLRISNLADQVGIKAIMVHAIDGKARAFYEYYGFVQSPIAANTLFYKI

Download         Length: 483 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11515.11 Da        Isoelectric Point: 5.8990

>AT248281 WP_168246960.1 NZ_CP099254:2462334-2462630 [Citrobacter freundii]
MEKLMQTSARKPTRDKQINIRATDEERAVIDYAASLVNKNRTDFIIEKAVHEAQNIILDQRVFVLDDARYQSFIEQLEAP
VQNVEGRQRLMDVKPEWK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References