Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4698799..4699315 Replicon chromosome
Accession NZ_CP099252
Organism Klebsiella aerogenes strain RHB11-E1-C08

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NFJ68_RS22705 Protein ID WP_046883307.1
Coordinates 4698799..4699083 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NFJ68_RS22710 Protein ID WP_002886901.1
Coordinates 4699073..4699315 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ68_RS22685 (NFJ68_22655) 4694214..4694477 - 264 WP_015368564.1 PTS sugar transporter subunit IIB -
NFJ68_RS22690 (NFJ68_22660) 4694784..4695527 + 744 WP_015704205.1 MurR/RpiR family transcriptional regulator -
NFJ68_RS22695 (NFJ68_22665) 4695885..4698023 + 2139 WP_015368566.1 anaerobic ribonucleoside-triphosphate reductase -
NFJ68_RS22700 (NFJ68_22670) 4698331..4698795 + 465 WP_015368567.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NFJ68_RS22705 (NFJ68_22675) 4698799..4699083 - 285 WP_046883307.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFJ68_RS22710 (NFJ68_22680) 4699073..4699315 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NFJ68_RS22715 (NFJ68_22685) 4699393..4701303 - 1911 WP_045364915.1 PRD domain-containing protein -
NFJ68_RS22720 (NFJ68_22690) 4701326..4702477 - 1152 WP_020079795.1 lactonase family protein -
NFJ68_RS22725 (NFJ68_22695) 4702544..4703284 - 741 WP_015368570.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11179.07 Da        Isoelectric Point: 10.4951

>T248270 WP_046883307.1 NZ_CP099252:c4699083-4698799 [Klebsiella aerogenes]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRMESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYRQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT248270 WP_002886901.1 NZ_CP099252:c4699315-4699073 [Klebsiella aerogenes]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References