Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4598631..4599441 Replicon chromosome
Accession NZ_CP099252
Organism Klebsiella aerogenes strain RHB11-E1-C08

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag NFJ68_RS22265 Protein ID WP_116289496.1
Coordinates 4598631..4599164 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NFJ68_RS22270 Protein ID WP_002887278.1
Coordinates 4599175..4599441 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ68_RS22260 (NFJ68_22230) 4597463..4598584 + 1122 WP_015704249.1 cupin domain-containing protein -
NFJ68_RS22265 (NFJ68_22235) 4598631..4599164 - 534 WP_116289496.1 type II toxin-antitoxin system toxin KacT Toxin
NFJ68_RS22270 (NFJ68_22240) 4599175..4599441 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NFJ68_RS22275 (NFJ68_22245) 4599520..4600977 - 1458 WP_086557054.1 Cu(+)/Ag(+) sensor histidine kinase -
NFJ68_RS22280 (NFJ68_22250) 4600967..4601650 - 684 WP_008807068.1 copper response regulator transcription factor CusR -
NFJ68_RS22285 (NFJ68_22255) 4601824..4603209 + 1386 WP_042894144.1 efflux transporter outer membrane subunit -
NFJ68_RS22290 (NFJ68_22260) 4603227..4603571 + 345 WP_042894147.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19936.85 Da        Isoelectric Point: 5.7150

>T248268 WP_116289496.1 NZ_CP099252:c4599164-4598631 [Klebsiella aerogenes]
MDQLLTIEMIADEFRYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGRGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT248268 WP_002887278.1 NZ_CP099252:c4599441-4599175 [Klebsiella aerogenes]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References