Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3944295..3944914 Replicon chromosome
Accession NZ_CP099252
Organism Klebsiella aerogenes strain RHB11-E1-C08

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag NFJ68_RS19185 Protein ID WP_015367918.1
Coordinates 3944696..3944914 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag NFJ68_RS19180 Protein ID WP_015367917.1
Coordinates 3944295..3944669 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ68_RS19170 (NFJ68_19140) 3939454..3940653 + 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFJ68_RS19175 (NFJ68_19145) 3940676..3943822 + 3147 WP_015367916.1 multidrug efflux RND transporter permease subunit AcrB -
NFJ68_RS19180 (NFJ68_19150) 3944295..3944669 + 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
NFJ68_RS19185 (NFJ68_19155) 3944696..3944914 + 219 WP_015367918.1 HHA domain-containing protein Toxin
NFJ68_RS19190 (NFJ68_19160) 3945046..3945609 + 564 WP_020079452.1 maltose O-acetyltransferase -
NFJ68_RS19195 (NFJ68_19165) 3945735..3946199 + 465 WP_015367920.1 YlaC family protein -
NFJ68_RS19200 (NFJ68_19170) 3946174..3947628 - 1455 WP_020079453.1 PLP-dependent aminotransferase family protein -
NFJ68_RS19205 (NFJ68_19175) 3947731..3948441 + 711 WP_015704607.1 GNAT family protein -
NFJ68_RS19210 (NFJ68_19180) 3948438..3948578 - 141 WP_020079454.1 type B 50S ribosomal protein L36 -
NFJ68_RS19215 (NFJ68_19185) 3948581..3948841 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T248266 WP_015367918.1 NZ_CP099252:3944696-3944914 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT248266 WP_015367917.1 NZ_CP099252:3944295-3944669 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References