Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 851229..851886 Replicon chromosome
Accession NZ_CP099252
Organism Klebsiella aerogenes strain RHB11-E1-C08

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag NFJ68_RS04125 Protein ID WP_015369792.1
Coordinates 851476..851886 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag NFJ68_RS04120 Protein ID WP_015369791.1
Coordinates 851229..851495 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ68_RS04095 (NFJ68_04095) 846456..847889 - 1434 WP_032712496.1 6-phospho-beta-glucosidase BglA -
NFJ68_RS04100 (NFJ68_04100) 848009..848737 - 729 WP_020077980.1 MurR/RpiR family transcriptional regulator -
NFJ68_RS04105 (NFJ68_04105) 848788..849099 + 312 WP_116289392.1 N(4)-acetylcytidine aminohydrolase -
NFJ68_RS04110 (NFJ68_04110) 849264..849923 + 660 WP_008806429.1 hemolysin III family protein -
NFJ68_RS04115 (NFJ68_04115) 850022..851005 - 984 WP_015369790.1 tRNA-modifying protein YgfZ -
NFJ68_RS04120 (NFJ68_04120) 851229..851495 + 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
NFJ68_RS04125 (NFJ68_04125) 851476..851886 + 411 WP_015369792.1 protein YgfX Toxin
NFJ68_RS04130 (NFJ68_04130) 851894..852415 - 522 WP_045387211.1 flavodoxin FldB -
NFJ68_RS04135 (NFJ68_04135) 852516..853412 + 897 WP_045414365.1 site-specific tyrosine recombinase XerD -
NFJ68_RS04140 (NFJ68_04140) 853435..854148 + 714 WP_116289391.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFJ68_RS04145 (NFJ68_04145) 854154..855887 + 1734 WP_015369796.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T248260 WP_015369792.1 NZ_CP099252:851476-851886 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT248260 WP_015369791.1 NZ_CP099252:851229-851495 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References