Detailed information of TA system TA024826

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4046912..4047557
• Replicon: chromosome
• Accession: NC_014306
• Organism: Erwinia billingiae Eb661

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: EBC_RS19880
• Protein ID: WP_041692112.1
• Coordinates: 4046912..4047310 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D8MWF5
• Locus tag: EBC_RS25235
• Protein ID: WP_013203646.1
• Coordinates: 4047291..4047557 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EBC_RS19860	4042832..4044550	-	1719	WP_013203641.1	single-stranded-DNA-specific exonuclease RecJ	-
EBC_RS19865	4044556..4045260	-	705	WP_013203642.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
EBC_RS19870	4045312..4046205	-	894	WP_013203643.1	site-specific tyrosine recombinase XerD	-
EBC_RS19875	4046304..4046822	+	519	WP_013203644.1	flavodoxin FldB	-
EBC_RS19880	4046912..4047310	-	399	WP_041692112.1	protein YgfX	Toxin
EBC_RS25235	4047291..4047557	-	267	WP_013203646.1	FAD assembly factor SdhE	Antitoxin
EBC_RS25850	4047577..4047750	-	174	WP_157868033.1	hypothetical protein	-
EBC_RS19890	4047775..4048758	+	984	WP_013203647.1	tRNA-modifying protein YgfZ	-
EBC_RS19895	4048799..4049452	-	654	WP_013203648.1	hemolysin III family protein	-
EBC_RS19900	4049714..4050322	+	609	WP_013203650.1	HD domain-containing protein	-
EBC_RS19905	4050322..4051050	+	729	WP_013203651.1	MurR/RpiR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-130)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15643.56 Da
• Isoelectric Point: 11.3944

>T24826 WP_041692112.1 NC_014306:c4047310-4046912 [Erwinia billingiae Eb661]
VALWHSDLRISWRAQWISLLLHGVVILALLLAPWPASFTLVWMLLLTLVVFECVRSQRRIRGREGVISLLEHQQMQWRQK
RWQICGRPWMTRQAIFLKLSSAKGEKEKLWLCRDSMDEGDWRALRQQLLTPG

Nucleotide

• Length: 399 bp

>T24826 NC_014306:c4047310-4046912 [Erwinia billingiae Eb661]
GTGGCCCTGTGGCACTCTGATTTACGGATCTCATGGCGTGCCCAGTGGATTTCTCTGTTGCTGCACGGCGTGGTGATCCT
TGCGCTGTTACTCGCGCCCTGGCCTGCCAGTTTCACCCTGGTGTGGATGCTGCTGCTGACGCTGGTGGTGTTTGAATGCG
TGCGCAGCCAGCGGCGGATCCGCGGTCGTGAAGGCGTGATTTCGCTGCTTGAGCATCAGCAAATGCAGTGGCGGCAGAAG
CGCTGGCAGATTTGTGGCCGCCCGTGGATGACCCGACAGGCGATTTTCCTGAAATTAAGCTCAGCGAAAGGCGAGAAGGA
AAAACTGTGGTTGTGCCGCGACAGCATGGATGAAGGCGACTGGCGGGCATTGCGTCAGCAGTTGCTGACGCCGGGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10456.90 Da
• Isoelectric Point: 4.7921

>AT24826 WP_013203646.1 NC_014306:c4047557-4047291 [Erwinia billingiae Eb661]
MDISNRARVHWACRRGMLELDIAIMPFFKFEYDTLDDNDKQQFVRLLESPDPDLFNWLMNHGEPDDAELKRIVNLIQQRN
QQRGPVAL

Nucleotide

• Length: 267 bp

>AT24826 NC_014306:c4047557-4047291 [Erwinia billingiae Eb661]
ATGGATATTAGTAACAGAGCACGGGTTCACTGGGCGTGCCGCCGTGGCATGCTTGAACTGGATATCGCCATCATGCCGTT
CTTCAAGTTTGAGTACGATACGCTGGACGACAATGACAAACAGCAGTTCGTGCGTCTGCTCGAAAGCCCCGATCCTGACC
TCTTTAACTGGCTGATGAATCACGGTGAGCCGGATGATGCTGAGCTGAAGCGGATAGTCAATTTGATCCAACAGCGAAAT
CAGCAACGTGGCCCTGTGGCACTCTGA

Structures

Antitoxin

• AlphaFold DB: D8MWF5