Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 261789..262420 Replicon chromosome
Accession NZ_CP099252
Organism Klebsiella aerogenes strain RHB11-E1-C08

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H3FL31
Locus tag NFJ68_RS01175 Protein ID WP_015703741.1
Coordinates 261789..262064 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H3FNK6
Locus tag NFJ68_RS01180 Protein ID WP_015703740.1
Coordinates 262061..262420 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ68_RS01155 (NFJ68_01155) 257018..257353 + 336 WP_015703743.1 universal stress protein UspB -
NFJ68_RS01160 (NFJ68_01160) 257418..258914 - 1497 WP_015369272.1 inorganic phosphate transporter PitA -
NFJ68_RS01165 (NFJ68_01165) 259145..260338 + 1194 WP_045413415.1 NAD(P)/FAD-dependent oxidoreductase -
NFJ68_RS01170 (NFJ68_01170) 260379..261392 - 1014 WP_015369274.1 magnesium transporter -
NFJ68_RS01175 (NFJ68_01175) 261789..262064 + 276 WP_015703741.1 type II toxin-antitoxin system HicA family toxin Toxin
NFJ68_RS01180 (NFJ68_01180) 262061..262420 + 360 WP_015703740.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFJ68_RS01185 (NFJ68_01185) 262448..262849 - 402 WP_020077744.1 nickel-responsive transcriptional regulator NikR -
NFJ68_RS01190 (NFJ68_01190) 262837..263628 - 792 WP_032715259.1 nickel import ATP-binding protein NikE -
NFJ68_RS01195 (NFJ68_01195) 263625..264389 - 765 WP_015369277.1 nickel import ATP-binding protein NikD -
NFJ68_RS01200 (NFJ68_01200) 264389..265222 - 834 WP_015369278.1 nickel ABC transporter permease subunit NikC -
NFJ68_RS01205 (NFJ68_01205) 265219..266163 - 945 WP_045386598.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10258.89 Da        Isoelectric Point: 10.4888

>T248259 WP_015703741.1 NZ_CP099252:261789-262064 [Klebsiella aerogenes]
MEQQVLSLRKKQRNTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13305.02 Da        Isoelectric Point: 4.3472

>AT248259 WP_015703740.1 NZ_CP099252:262061-262420 [Klebsiella aerogenes]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCREAGIEPYAQPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FL31

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FNK6

References