248258

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 75146..76167 Replicon chromosome
Accession NZ_CP099252
Organism Klebsiella aerogenes strain RHB11-E1-C08

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A0G9UXE3
Locus tag NFJ68_RS00375 Protein ID WP_032706547.1
Coordinates 75592..76167 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag NFJ68_RS00370 Protein ID WP_047043205.1
Coordinates 75146..75592 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ68_RS00345 (NFJ68_00345) 70667..71446 + 780 WP_015703851.1 MBL fold metallo-hydrolase -
NFJ68_RS00350 (NFJ68_00350) 71468..72421 + 954 WP_015703850.1 helix-turn-helix domain-containing protein -
NFJ68_RS00355 (NFJ68_00355) 72418..73467 - 1050 WP_063445250.1 NAD(P)-dependent alcohol dehydrogenase -
NFJ68_RS00360 (NFJ68_00360) 73625..73927 - 303 WP_042893661.1 putative quinol monooxygenase -
NFJ68_RS00365 (NFJ68_00365) 73928..74935 - 1008 WP_042893659.1 zinc-binding alcohol dehydrogenase family protein -
NFJ68_RS00370 (NFJ68_00370) 75146..75592 + 447 WP_047043205.1 helix-turn-helix domain-containing protein Antitoxin
NFJ68_RS00375 (NFJ68_00375) 75592..76167 + 576 WP_032706547.1 PIN domain-containing protein Toxin
NFJ68_RS00380 (NFJ68_00380) 76472..77668 + 1197 WP_042893658.1 hypothetical protein -
NFJ68_RS00385 (NFJ68_00385) 77951..78988 - 1038 WP_045411414.1 virulence RhuM family protein -
NFJ68_RS00390 (NFJ68_00390) 79223..79511 - 289 Protein_77 SymE family type I addiction module toxin -
NFJ68_RS00395 (NFJ68_00395) 79583..79885 - 303 WP_020077664.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-115)

Antitoxin

SinI-like, DNA-binding domain

(79-126)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21688.29 Da        Isoelectric Point: 6.2900

>T248258 WP_032706547.1 NZ_CP099252:75592-76167 [Klebsiella aerogenes]
MRHSPYPVILDACVLYPARLRDLLMHLGIAGLYQPKWSRFIHDEWCRNLLINRPDIAPEALRRTVDLMNAALPDANVTGF
AGLINGLVLPDPDDRHVLAAAIRAKAEIIVTLNHKDFPAESLLPFEIETLHPDVFISDLFDLNHALALEAVRRQRQSLKH
PPMTVDEFLEMLLKQGLPMTVKELANYQYAI

Download         Length: 576 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16698.27 Da        Isoelectric Point: 6.4921

>AT248258 WP_047043205.1 NZ_CP099252:75146-75592 [Klebsiella aerogenes]
MTKLNLPNPLESELAQRGQRELAAYLSTHLETQRIAIVGEDDKTHTIELPTSALTMLMEILGELACGNAVQIVPVHAELT
TQEAANILNVSRPHMVKLLEARKLPFHKTGRHRRVLFADLMEYKKRREQESLDAMQALADQAQDLGMY

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G9UXE3

Antitoxin

Source ID Structure

References