Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 180729..181630 Replicon plasmid unnamed1
Accession NZ_CP099218
Organism Citrobacter freundii strain RHB16-SO-C03

Toxin (Protein)


Gene name - Uniprot ID A0A837LJP8
Locus tag NFJ87_RS26145 Protein ID WP_007372300.1
Coordinates 180729..181187 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag NFJ87_RS26150 Protein ID WP_008786588.1
Coordinates 181184..181630 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ87_RS26100 (NFJ87_26085) 176410..176697 + 288 WP_016241556.1 hypothetical protein -
NFJ87_RS26105 (NFJ87_26090) 176708..177106 + 399 WP_007372292.1 hypothetical protein -
NFJ87_RS26110 (NFJ87_26095) 177190..177516 + 327 WP_007372293.1 hypothetical protein -
NFJ87_RS26115 (NFJ87_26100) 177879..178217 - 339 WP_007372294.1 hypothetical protein -
NFJ87_RS26120 (NFJ87_26105) 178455..178898 + 444 WP_007372295.1 hypothetical protein -
NFJ87_RS26125 (NFJ87_26110) 179017..179358 + 342 WP_007372296.1 hypothetical protein -
NFJ87_RS26130 (NFJ87_26115) 179517..180071 + 555 WP_007372297.1 hypothetical protein -
NFJ87_RS26135 (NFJ87_26120) 180121..180387 + 267 WP_007372298.1 hypothetical protein -
NFJ87_RS26140 (NFJ87_26125) 180455..180685 - 231 WP_007372299.1 hypothetical protein -
NFJ87_RS26145 (NFJ87_26130) 180729..181187 - 459 WP_007372300.1 RES family NAD+ phosphorylase Toxin
NFJ87_RS26150 (NFJ87_26135) 181184..181630 - 447 WP_008786588.1 DUF2384 domain-containing protein Antitoxin
NFJ87_RS26155 (NFJ87_26140) 181779..182096 + 318 WP_007372302.1 hypothetical protein -
NFJ87_RS26160 (NFJ87_26145) 182138..182980 + 843 WP_007372303.1 hypothetical protein -
NFJ87_RS26165 (NFJ87_26150) 182952..183230 + 279 WP_007372304.1 hypothetical protein -
NFJ87_RS26170 (NFJ87_26155) 183290..183733 + 444 WP_007372305.1 hypothetical protein -
NFJ87_RS26175 (NFJ87_26160) 184020..184184 + 165 WP_007372306.1 hypothetical protein -
NFJ87_RS26180 (NFJ87_26165) 184752..185594 + 843 WP_007372307.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..217792 217792


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(95-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16975.40 Da        Isoelectric Point: 4.5730

>T248246 WP_007372300.1 NZ_CP099218:c181187-180729 [Citrobacter freundii]
VILYRLTKTRYLMTAWSGLGAKEAGGRWNSVGTAMVYLSETASLTMLETLVHIHAPQLLDDFTLLSLDVPDDQIQTFDMS
RLPDNWASEDAPAELALYGDNWAESGSSIALRIPSALSPVEFNYLLNPAHPELFDLMATVKKIPFRFDSRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16689.02 Da        Isoelectric Point: 6.9812

>AT248246 WP_008786588.1 NZ_CP099218:c181630-181184 [Citrobacter freundii]
MTMKVFSPDVTKTNQHCLWQVAGLDNDGIALMDKINHGLDGTVAKHISEWANITPSELRKMSGIPNTTFNRSIKDRFTAD
QSERLVRIIRVIERAVELFEGDKEAAHKWLNEANRGLSWKSPAELVSSETGALEVMRLITRIEHGVYS

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837LJP8

Antitoxin

Source ID Structure

References