Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4980092..4980708 Replicon chromosome
Accession NZ_CP099217
Organism Citrobacter freundii strain RHB16-SO-C03

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NFJ87_RS24160 Protein ID WP_279270486.1
Coordinates 4980092..4980466 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6B5NTK4
Locus tag NFJ87_RS24165 Protein ID WP_043018956.1
Coordinates 4980466..4980708 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ87_RS24145 (4977595) 4977595..4978497 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
NFJ87_RS24150 (4978494) 4978494..4979129 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
NFJ87_RS24155 (4979126) 4979126..4980055 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
NFJ87_RS24160 (4980092) 4980092..4980466 - 375 WP_279270486.1 type II toxin-antitoxin system VapC family toxin Toxin
NFJ87_RS24165 (4980466) 4980466..4980708 - 243 WP_043018956.1 CopG family transcriptional regulator Antitoxin
NFJ87_RS24170 (4980914) 4980914..4981822 + 909 WP_279270487.1 alpha/beta hydrolase -
NFJ87_RS24175 (4981973) 4981973..4982914 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
NFJ87_RS24180 (4982959) 4982959..4983396 - 438 WP_003028671.1 D-aminoacyl-tRNA deacylase -
NFJ87_RS24185 (4983393) 4983393..4984265 - 873 WP_060854619.1 virulence factor BrkB family protein -
NFJ87_RS24190 (4984259) 4984259..4984858 - 600 WP_279270488.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13655.84 Da        Isoelectric Point: 8.5343

>T248243 WP_279270486.1 NZ_CP099217:c4980466-4980092 [Citrobacter freundii]
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHHLTLVTRNTKDFAGLSGVVTPYTL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9451.75 Da        Isoelectric Point: 4.3437

>AT248243 WP_043018956.1 NZ_CP099217:c4980708-4980466 [Citrobacter freundii]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6B5NTK4

References