Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4586953..4587469 Replicon chromosome
Accession NZ_CP099217
Organism Citrobacter freundii strain RHB16-SO-C03

Toxin (Protein)


Gene name relE Uniprot ID A0A0J1MTE6
Locus tag NFJ87_RS22400 Protein ID WP_016149473.1
Coordinates 4587185..4587469 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag NFJ87_RS22395 Protein ID WP_003839576.1
Coordinates 4586953..4587195 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ87_RS22375 (4581968) 4581968..4583101 + 1134 WP_048241739.1 amidohydrolase/deacetylase family metallohydrolase -
NFJ87_RS22380 (4583085) 4583085..4584203 + 1119 WP_048216923.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NFJ87_RS22385 (4584200) 4584200..4584940 + 741 WP_048216922.1 KDGP aldolase family protein -
NFJ87_RS22390 (4584962) 4584962..4586875 + 1914 WP_048241736.1 BglG family transcription antiterminator -
NFJ87_RS22395 (4586953) 4586953..4587195 + 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NFJ87_RS22400 (4587185) 4587185..4587469 + 285 WP_016149473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFJ87_RS22405 (4587473) 4587473..4587937 - 465 WP_279270436.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NFJ87_RS22410 (4588122) 4588122..4590260 - 2139 WP_003025782.1 anaerobic ribonucleoside-triphosphate reductase -
NFJ87_RS22415 (4590669) 4590669..4592321 - 1653 WP_279270437.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10878.73 Da        Isoelectric Point: 10.0482

>T248241 WP_016149473.1 NZ_CP099217:4587185-4587469 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT248241 WP_003839576.1 NZ_CP099217:4586953-4587195 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MTE6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References