Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3790866..3791486 Replicon chromosome
Accession NZ_CP099217
Organism Citrobacter freundii strain RHB16-SO-C03

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFJ87_RS18705 Protein ID WP_002892050.1
Coordinates 3791268..3791486 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag NFJ87_RS18700 Protein ID WP_003021733.1
Coordinates 3790866..3791240 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ87_RS18690 (3786012) 3786012..3787205 + 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFJ87_RS18695 (3787228) 3787228..3790377 + 3150 WP_003021736.1 efflux RND transporter permease AcrB -
NFJ87_RS18700 (3790866) 3790866..3791240 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
NFJ87_RS18705 (3791268) 3791268..3791486 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFJ87_RS18710 (3791793) 3791793..3792344 + 552 WP_003835924.1 maltose O-acetyltransferase -
NFJ87_RS18715 (3792461) 3792461..3792931 + 471 WP_003021724.1 YlaC family protein -
NFJ87_RS18720 (3793010) 3793010..3793150 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFJ87_RS18725 (3793152) 3793152..3793412 - 261 WP_003835926.1 type B 50S ribosomal protein L31 -
NFJ87_RS18730 (3793601) 3793601..3795154 + 1554 WP_003835927.1 EAL domain-containing protein -
NFJ87_RS18735 (3795206) 3795206..3795559 - 354 WP_003831033.1 DUF1428 family protein -
NFJ87_RS18740 (3795624) 3795624..3796253 - 630 WP_003835929.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248239 WP_002892050.1 NZ_CP099217:3791268-3791486 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT248239 WP_003021733.1 NZ_CP099217:3790866-3791240 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References