Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2494228..2494867 Replicon chromosome
Accession NZ_CP099217
Organism Citrobacter freundii strain RHB16-SO-C03

Toxin (Protein)


Gene name hicA Uniprot ID A0A8B5QF36
Locus tag NFJ87_RS12240 Protein ID WP_003020221.1
Coordinates 2494228..2494404 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NFJ87_RS12245 Protein ID WP_123924900.1
Coordinates 2494451..2494867 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ87_RS12220 (2491007) 2491007..2491237 - 231 WP_048217543.1 DUF2554 family protein -
NFJ87_RS12225 (2491426) 2491426..2491551 - 126 WP_003020230.1 DUF2474 domain-containing protein -
NFJ87_RS12230 (2491551) 2491551..2492561 - 1011 WP_003020227.1 cytochrome d ubiquinol oxidase subunit II -
NFJ87_RS12235 (2492561) 2492561..2493964 - 1404 WP_003843730.1 cytochrome ubiquinol oxidase subunit I -
NFJ87_RS12240 (2494228) 2494228..2494404 + 177 WP_003020221.1 type II toxin-antitoxin system HicA family toxin Toxin
NFJ87_RS12245 (2494451) 2494451..2494867 + 417 WP_123924900.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFJ87_RS12250 (2494960) 2494960..2496369 + 1410 WP_279270871.1 PLP-dependent aminotransferase family protein -
NFJ87_RS12255 (2496698) 2496698..2497843 + 1146 WP_003020212.1 ABC transporter substrate-binding protein -
NFJ87_RS12260 (2497860) 2497860..2498876 + 1017 WP_003020210.1 ABC transporter ATP-binding protein -
NFJ87_RS12265 (2498877) 2498877..2499821 + 945 WP_279270872.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6769.80 Da        Isoelectric Point: 11.2510

>T248238 WP_003020221.1 NZ_CP099217:2494228-2494404 [Citrobacter freundii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIIKQLDLQ

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15126.36 Da        Isoelectric Point: 4.5716

>AT248238 WP_123924900.1 NZ_CP099217:2494451-2494867 [Citrobacter freundii]
MRYPVTLTPAVEGGFVVSFPDIPEALTQGNTRHDALQAAQAALITAFEFYFDDNEAIPLPSAVSAEDDYVEIPLSVASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHTTKIDAVQIAARALGKELALTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5QF36

Antitoxin

Source ID Structure

References