Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 927957..928759 Replicon chromosome
Accession NZ_CP099217
Organism Citrobacter freundii strain RHB16-SO-C03

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag NFJ87_RS04655 Protein ID WP_048213143.1
Coordinates 928373..928759 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag NFJ87_RS04650 Protein ID WP_048213144.1
Coordinates 927957..928316 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ87_RS04620 (924478) 924478..924693 - 216 WP_048213495.1 AlpA family phage regulatory protein -
NFJ87_RS04625 (924814) 924814..925437 - 624 WP_048213148.1 inovirus Gp2 family protein -
NFJ87_RS04630 (925902) 925902..926723 + 822 WP_048213147.1 DUF932 domain-containing protein -
NFJ87_RS04635 (926756) 926756..927205 + 450 WP_048213146.1 antirestriction protein -
NFJ87_RS04640 (927217) 927217..927696 + 480 WP_048213145.1 DNA repair protein RadC -
NFJ87_RS04645 (927711) 927711..927932 + 222 WP_004192297.1 DUF987 domain-containing protein -
NFJ87_RS04650 (927957) 927957..928316 + 360 WP_048213144.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NFJ87_RS04655 (928373) 928373..928759 + 387 WP_048213143.1 TA system toxin CbtA family protein Toxin
NFJ87_RS04660 (928846) 928846..929685 + 840 WP_048213142.1 DUF4942 domain-containing protein -
NFJ87_RS04665 (929891) 929891..930427 - 537 WP_279270588.1 GNAT family N-acetyltransferase -
NFJ87_RS04670 (931253) 931253..933706 + 2454 WP_223232868.1 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(8-110)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14428.55 Da        Isoelectric Point: 8.9843

>T248233 WP_048213143.1 NZ_CP099217:928373-928759 [Citrobacter freundii]
MQTKLPFMRAASSRPSPVDVWQTLLTCLLEHHYGLTLSDTPFSDEQVIQQHIDAGISLVDALNFIVEKYELVRTDRPGFS
IMEQSPFITAIDILRARKATGLMNRGTYKEVTAITRGQHPQARTSGKR

Download         Length: 387 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13313.12 Da        Isoelectric Point: 6.6251

>AT248233 WP_048213144.1 NZ_CP099217:927957-928316 [Citrobacter freundii]
MSKNTTITTHDISEPWWGLRRSVSPCFGARLVQEGNRLYYLADRANVSGQFCDADLRHLDQSFPVLMKQLELMLTSGELN
PRHQHGVTLCAKGLTCEADTLGSHGYVYIAIYPTPVTTE

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References