Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 897109..897763 Replicon chromosome
Accession NZ_CP099217
Organism Citrobacter freundii strain RHB16-SO-C03

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag NFJ87_RS04495 Protein ID WP_003026936.1
Coordinates 897356..897763 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag NFJ87_RS04490 Protein ID WP_003026938.1
Coordinates 897109..897375 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ87_RS04465 (892310) 892310..893743 - 1434 WP_048218552.1 6-phospho-beta-glucosidase BglA -
NFJ87_RS04470 (893864) 893864..894592 - 729 WP_060855085.1 MurR/RpiR family transcriptional regulator -
NFJ87_RS04475 (894645) 894645..894956 + 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
NFJ87_RS04480 (895119) 895119..895778 + 660 WP_003026947.1 hemolysin III family protein -
NFJ87_RS04485 (895872) 895872..896852 - 981 WP_003838269.1 tRNA-modifying protein YgfZ -
NFJ87_RS04490 (897109) 897109..897375 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
NFJ87_RS04495 (897356) 897356..897763 + 408 WP_003026936.1 protein YgfX Toxin
NFJ87_RS04500 (897808) 897808..898329 - 522 WP_003026933.1 flavodoxin FldB -
NFJ87_RS04505 (898443) 898443..899339 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
NFJ87_RS04510 (899363) 899363..900076 + 714 WP_279270585.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFJ87_RS04515 (900082) 900082..901815 + 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T248232 WP_003026936.1 NZ_CP099217:897356-897763 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT248232 WP_003026938.1 NZ_CP099217:897109-897375 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References