Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4668224..4668740 Replicon chromosome
Accession NZ_CP099140
Organism Klebsiella pneumoniae strain RHB28-SO-C05

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NFK38_RS22790 Protein ID WP_040216106.1
Coordinates 4668224..4668508 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NFK38_RS22795 Protein ID WP_002886901.1
Coordinates 4668498..4668740 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK38_RS22765 (NFK38_22750) 4663641..4663904 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
NFK38_RS22770 (NFK38_22755) 4664034..4664207 + 174 WP_004146781.1 hypothetical protein -
NFK38_RS22775 (NFK38_22760) 4664210..4664953 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NFK38_RS22780 (NFK38_22765) 4665310..4667448 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NFK38_RS22785 (NFK38_22770) 4667756..4668220 + 465 WP_032418146.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NFK38_RS22790 (NFK38_22775) 4668224..4668508 - 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFK38_RS22795 (NFK38_22780) 4668498..4668740 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NFK38_RS22800 (NFK38_22785) 4668818..4670728 - 1911 WP_040216105.1 PRD domain-containing protein -
NFK38_RS22805 (NFK38_22790) 4670751..4671905 - 1155 WP_002886900.1 lactonase family protein -
NFK38_RS22810 (NFK38_22795) 4671972..4672712 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T248226 WP_040216106.1 NZ_CP099140:c4668508-4668224 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT248226 WP_002886901.1 NZ_CP099140:c4668740-4668498 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References