Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4559248..4560058 Replicon chromosome
Accession NZ_CP099140
Organism Klebsiella pneumoniae strain RHB28-SO-C05

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag NFK38_RS22330 Protein ID WP_048337996.1
Coordinates 4559248..4559781 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NFK38_RS22335 Protein ID WP_002887278.1
Coordinates 4559792..4560058 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK38_RS22325 (NFK38_22310) 4558079..4559200 + 1122 WP_004214138.1 cupin domain-containing protein -
NFK38_RS22330 (NFK38_22315) 4559248..4559781 - 534 WP_048337996.1 type II toxin-antitoxin system toxin KacT Toxin
NFK38_RS22335 (NFK38_22320) 4559792..4560058 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NFK38_RS22340 (NFK38_22325) 4560161..4561594 - 1434 WP_044245276.1 Cu(+)/Ag(+) sensor histidine kinase -
NFK38_RS22345 (NFK38_22330) 4561584..4562267 - 684 WP_032105399.1 copper response regulator transcription factor CusR -
NFK38_RS22350 (NFK38_22335) 4562439..4563824 + 1386 WP_048337995.1 efflux transporter outer membrane subunit -
NFK38_RS22355 (NFK38_22340) 4563842..4564186 + 345 WP_021462623.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19824.68 Da        Isoelectric Point: 5.2614

>T248225 WP_048337996.1 NZ_CP099140:c4559781-4559248 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSLQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT248225 WP_002887278.1 NZ_CP099140:c4560058-4559792 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References