Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2624268..2625856 Replicon chromosome
Accession NZ_CP099140
Organism Klebsiella pneumoniae strain RHB28-SO-C05

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NFK38_RS12980 Protein ID WP_048337706.1
Coordinates 2624268..2625590 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NFK38_RS12985 Protein ID WP_002904790.1
Coordinates 2625590..2625856 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK38_RS12965 (NFK38_12960) 2619324..2621825 + 2502 WP_048337707.1 fimbria/pilus outer membrane usher protein -
NFK38_RS12970 (NFK38_12965) 2621813..2622817 + 1005 WP_048265557.1 fimbrial protein -
NFK38_RS12975 (NFK38_12970) 2622959..2624251 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NFK38_RS12980 (NFK38_12975) 2624268..2625590 - 1323 WP_048337706.1 type II toxin-antitoxin system HipA family toxin Toxin
NFK38_RS12985 (NFK38_12980) 2625590..2625856 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NFK38_RS12990 (NFK38_12985) 2626122..2626448 - 327 WP_048265555.1 hydroxyisourate hydrolase -
NFK38_RS12995 (NFK38_12990) 2626445..2626945 - 501 WP_048337705.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NFK38_RS13000 (NFK38_12995) 2626923..2628302 - 1380 WP_048337704.1 nucleobase:cation symporter-2 family protein -
NFK38_RS13005 (NFK38_13000) 2628648..2629802 + 1155 WP_048337703.1 FAD-dependent urate hydroxylase HpxO -
NFK38_RS13010 (NFK38_13005) 2629783..2630706 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49127.41 Da        Isoelectric Point: 7.5357

>T248222 WP_048337706.1 NZ_CP099140:c2625590-2624268 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDVISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT248222 WP_002904790.1 NZ_CP099140:c2625856-2625590 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References