Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 789284..789941 Replicon chromosome
Accession NZ_CP099140
Organism Klebsiella pneumoniae strain RHB28-SO-C05

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NFK38_RS03930 Protein ID WP_002916310.1
Coordinates 789531..789941 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NFK38_RS03925 Protein ID WP_002916312.1
Coordinates 789284..789550 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK38_RS03900 (NFK38_03900) 784440..785873 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NFK38_RS03905 (NFK38_03905) 785992..786720 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NFK38_RS03910 (NFK38_03910) 786770..787081 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NFK38_RS03915 (NFK38_03915) 787245..787904 + 660 WP_002916317.1 hemolysin III family protein -
NFK38_RS03920 (NFK38_03920) 788055..789038 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NFK38_RS03925 (NFK38_03925) 789284..789550 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NFK38_RS03930 (NFK38_03930) 789531..789941 + 411 WP_002916310.1 protein YgfX Toxin
NFK38_RS03935 (NFK38_03935) 789948..790469 - 522 WP_004144730.1 flavodoxin FldB -
NFK38_RS03940 (NFK38_03940) 790570..791466 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NFK38_RS03945 (NFK38_03945) 791489..792202 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFK38_RS03950 (NFK38_03950) 792208..793941 + 1734 WP_065807532.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T248217 WP_002916310.1 NZ_CP099140:789531-789941 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT248217 WP_002916312.1 NZ_CP099140:789284-789550 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References