Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4414691..4415479 Replicon chromosome
Accession NZ_CP099128
Organism Citrobacter freundii strain RHB31-E4-C06

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7L6ILI8
Locus tag NFK47_RS21225 Protein ID WP_047359063.1
Coordinates 4415102..4415479 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag NFK47_RS21220 Protein ID WP_047363950.1
Coordinates 4414691..4415050 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK47_RS21180 (4409947) 4409947..4410768 + 822 WP_149330777.1 DUF932 domain-containing protein -
NFK47_RS21185 (4410985) 4410985..4411686 + 702 WP_149330776.1 WYL domain-containing protein -
NFK47_RS21190 (4411869) 4411869..4412564 + 696 WP_149330775.1 hypothetical protein -
NFK47_RS21195 (4412586) 4412586..4413059 + 474 WP_149330774.1 hypothetical protein -
NFK47_RS21200 (4413137) 4413137..4413376 + 240 WP_047359067.1 DUF905 domain-containing protein -
NFK47_RS21205 (4413473) 4413473..4413934 + 462 WP_047359066.1 antirestriction protein -
NFK47_RS21210 (4413946) 4413946..4414425 + 480 WP_047359065.1 DNA repair protein RadC -
NFK47_RS21215 (4414446) 4414446..4414667 + 222 WP_000691982.1 DUF987 domain-containing protein -
NFK47_RS21220 (4414691) 4414691..4415050 + 360 WP_047363950.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NFK47_RS21225 (4415102) 4415102..4415479 + 378 WP_047359063.1 TA system toxin CbtA family protein Toxin
NFK47_RS21230 (4415476) 4415476..4415967 + 492 WP_149330773.1 DUF5983 family protein -
NFK47_RS21235 (4415996) 4415996..4416199 + 204 WP_047359061.1 DUF957 domain-containing protein -
NFK47_RS21240 (4416278) 4416278..4417126 + 849 WP_149330772.1 DUF4942 domain-containing protein -
NFK47_RS21245 (4417928) 4417928..4419589 + 1662 WP_279278675.1 fatty acid--CoA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(2-110)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14078.86 Da        Isoelectric Point: 7.0606

>T248213 WP_047359063.1 NZ_CP099128:4415102-4415479 [Citrobacter freundii]
VQTQPLSSTHETSPRPSPVDIWQHLLNHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
SADTQSPLIGSIDILRARKATGLMTRHGYRPVTDLITGKYKKEQQ

Download         Length: 378 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13207.00 Da        Isoelectric Point: 6.7434

>AT248213 WP_047363950.1 NZ_CP099128:4414691-4415050 [Citrobacter freundii]
MSNKIPAENHDITEPWWGLKRSITPCFGARLVQEGNRLHYLADRASIAGTFSDADLRHLDQAFPVQLKQLELMLVSGELN
PRHQHCVTLYSKGLTCEADSLGSHGYVYIAIYPTPAATA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6ILI8

Antitoxin

Source ID Structure

References