Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4238303..4238819 Replicon chromosome
Accession NZ_CP099128
Organism Citrobacter freundii strain RHB31-E4-C06

Toxin (Protein)


Gene name relE Uniprot ID A0A0D7LMW6
Locus tag NFK47_RS20335 Protein ID WP_003839578.1
Coordinates 4238303..4238587 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag NFK47_RS20340 Protein ID WP_003839576.1
Coordinates 4238577..4238819 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK47_RS20320 (4233529) 4233529..4235181 + 1653 WP_279278667.1 alpha,alpha-phosphotrehalase -
NFK47_RS20325 (4235590) 4235590..4237728 + 2139 WP_003844922.1 anaerobic ribonucleoside-triphosphate reductase -
NFK47_RS20330 (4237835) 4237835..4238299 + 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NFK47_RS20335 (4238303) 4238303..4238587 - 285 WP_003839578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFK47_RS20340 (4238577) 4238577..4238819 - 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NFK47_RS20345 (4238897) 4238897..4240810 - 1914 WP_115454863.1 BglG family transcription antiterminator -
NFK47_RS20350 (4240832) 4240832..4241572 - 741 WP_048216922.1 KDGP aldolase family protein -
NFK47_RS20355 (4241569) 4241569..4242687 - 1119 WP_054527995.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NFK47_RS20360 (4242671) 4242671..4243804 - 1134 WP_060855415.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.68 Da        Isoelectric Point: 10.0482

>T248212 WP_003839578.1 NZ_CP099128:c4238587-4238303 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT248212 WP_003839576.1 NZ_CP099128:c4238819-4238577 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LMW6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References