Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3590510..3591130 Replicon chromosome
Accession NZ_CP099128
Organism Citrobacter freundii strain RHB31-E4-C06

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFK47_RS17390 Protein ID WP_002892050.1
Coordinates 3590912..3591130 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag NFK47_RS17385 Protein ID WP_003021733.1
Coordinates 3590510..3590884 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK47_RS17375 (3585657) 3585657..3586850 + 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFK47_RS17380 (3586873) 3586873..3590022 + 3150 WP_003021736.1 efflux RND transporter permease AcrB -
NFK47_RS17385 (3590510) 3590510..3590884 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
NFK47_RS17390 (3590912) 3590912..3591130 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFK47_RS17395 (3591437) 3591437..3591988 + 552 WP_032936967.1 maltose O-acetyltransferase -
NFK47_RS17400 (3592105) 3592105..3592575 + 471 WP_003021724.1 YlaC family protein -
NFK47_RS17405 (3592654) 3592654..3592794 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFK47_RS17410 (3592796) 3592796..3593056 - 261 WP_003021719.1 type B 50S ribosomal protein L31 -
NFK47_RS17415 (3593245) 3593245..3594798 + 1554 WP_003835927.1 EAL domain-containing protein -
NFK47_RS17420 (3594850) 3594850..3595203 - 354 WP_003831033.1 DUF1428 family protein -
NFK47_RS17425 (3595268) 3595268..3595897 - 630 WP_279278606.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248211 WP_002892050.1 NZ_CP099128:3590912-3591130 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT248211 WP_003021733.1 NZ_CP099128:3590510-3590884 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References