Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 825508..826162 Replicon chromosome
Accession NZ_CP099128
Organism Citrobacter freundii strain RHB31-E4-C06

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag NFK47_RS04060 Protein ID WP_003026936.1
Coordinates 825755..826162 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag NFK47_RS04055 Protein ID WP_003026938.1
Coordinates 825508..825774 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK47_RS04030 (820709) 820709..822142 - 1434 WP_003838263.1 6-phospho-beta-glucosidase BglA -
NFK47_RS04035 (822263) 822263..822991 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
NFK47_RS04040 (823044) 823044..823355 + 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
NFK47_RS04045 (823518) 823518..824177 + 660 WP_003026947.1 hemolysin III family protein -
NFK47_RS04050 (824271) 824271..825251 - 981 WP_016150946.1 tRNA-modifying protein YgfZ -
NFK47_RS04055 (825508) 825508..825774 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
NFK47_RS04060 (825755) 825755..826162 + 408 WP_003026936.1 protein YgfX Toxin
NFK47_RS04065 (826207) 826207..826728 - 522 WP_003026933.1 flavodoxin FldB -
NFK47_RS04070 (826842) 826842..827738 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
NFK47_RS04075 (827762) 827762..828475 + 714 WP_279278771.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFK47_RS04080 (828481) 828481..830214 + 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T248204 WP_003026936.1 NZ_CP099128:825755-826162 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT248204 WP_003026938.1 NZ_CP099128:825508-825774 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References