Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 251407..252038 Replicon chromosome
Accession NZ_CP099128
Organism Citrobacter freundii strain RHB31-E4-C06

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag NFK47_RS01190 Protein ID WP_003837806.1
Coordinates 251407..251682 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag NFK47_RS01195 Protein ID WP_003837808.1
Coordinates 251679..252038 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK47_RS01180 (247458) 247458..250205 + 2748 WP_032937231.1 ribosome-associated ATPase/putative transporter RbbA -
NFK47_RS01185 (250205) 250205..251329 + 1125 WP_200083132.1 ABC transporter permease -
NFK47_RS01190 (251407) 251407..251682 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
NFK47_RS01195 (251679) 251679..252038 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFK47_RS01200 (252151) 252151..252552 - 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
NFK47_RS01205 (252602) 252602..253180 - 579 WP_003023390.1 4'-phosphopantetheinyl transferase AcpT -
NFK47_RS01210 (253243) 253243..254292 - 1050 WP_003023393.1 AI-2E family transporter -
NFK47_RS01215 (254426) 254426..255643 + 1218 WP_003846164.1 MFS transporter -
NFK47_RS01220 (255647) 255647..256204 - 558 WP_003837816.1 DcrB family lipoprotein -
NFK47_RS01225 (256277) 256277..256942 - 666 WP_003837818.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T248201 WP_003837806.1 NZ_CP099128:251407-251682 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT248201 WP_003837808.1 NZ_CP099128:251679-252038 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References