Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4652629..4653227 Replicon chromosome
Accession NZ_CP099084
Organism Citrobacter freundii strain RHB43-C17

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NFK79_RS22355 Protein ID WP_181498734.1
Coordinates 4652629..4653003 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NFK79_RS22360 Protein ID WP_170975228.1
Coordinates 4653003..4653227 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK79_RS22340 (4650133) 4650133..4651035 + 903 WP_096758857.1 formate dehydrogenase O subunit beta -
NFK79_RS22345 (4651032) 4651032..4651667 + 636 WP_096758858.1 formate dehydrogenase cytochrome b556 subunit -
NFK79_RS22350 (4651664) 4651664..4652593 + 930 WP_181498733.1 formate dehydrogenase accessory protein FdhE -
NFK79_RS22355 (4652629) 4652629..4653003 - 375 WP_181498734.1 type II toxin-antitoxin system VapC family toxin Toxin
NFK79_RS22360 (4653003) 4653003..4653227 - 225 WP_170975228.1 CopG family transcriptional regulator Antitoxin
NFK79_RS22365 (4653450) 4653450..4654364 + 915 WP_181498735.1 alpha/beta hydrolase -
NFK79_RS22370 (4654404) 4654404..4655345 - 942 WP_153064726.1 fatty acid biosynthesis protein FabY -
NFK79_RS22375 (4655390) 4655390..4655827 - 438 WP_279264522.1 D-aminoacyl-tRNA deacylase -
NFK79_RS22380 (4655830) 4655830..4656696 - 867 WP_181498737.1 virulence factor BrkB family protein -
NFK79_RS22385 (4656690) 4656690..4657289 - 600 WP_096758866.1 glucose-1-phosphatase -
NFK79_RS22390 (4657395) 4657395..4658198 - 804 WP_096758867.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

Ribbon-helix-helix protein, CopG

(7-41)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13955.13 Da        Isoelectric Point: 8.4538

>T248200 WP_181498734.1 NZ_CP099084:c4653003-4652629 [Citrobacter freundii]
MVNGSALFDTNILIDLFSGRAEAKYAIETWPPQNAISLITWMEVMVGAKKYRQESRTRVALSAFNIIGVSQDIAERSVRL
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAEIPGVITPYQE

Download         Length: 375 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8701.75 Da        Isoelectric Point: 4.2075

>AT248200 WP_170975228.1 NZ_CP099084:c4653227-4653003 [Citrobacter freundii]
MGRILLDLSDEVIQRLDDLKVQRNLPRAELLREAVEQYLERQDNAETTISGALGLWQGCEEDGVEYQRKLREEW

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References