Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4497950..4498616 Replicon chromosome
Accession NZ_CP099084
Organism Citrobacter freundii strain RHB43-C17

Toxin (Protein)


Gene name tad Uniprot ID A0A6N6K5Y9
Locus tag NFK79_RS21665 Protein ID WP_005132818.1
Coordinates 4498257..4498616 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag NFK79_RS21660 Protein ID WP_096758754.1
Coordinates 4497950..4498267 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK79_RS21620 (4493559) 4493559..4494317 + 759 WP_096758746.1 DeoR/GlpR family DNA-binding transcription regulator -
NFK79_RS21625 (4494391) 4494391..4494663 + 273 WP_096758747.1 DUF3811 domain-containing protein -
NFK79_RS21630 (4494660) 4494660..4495535 - 876 WP_181490732.1 23S rRNA pseudouridine(2604) synthase RluF -
NFK79_RS21635 (4495786) 4495786..4496103 - 318 WP_117343617.1 CcdB family protein -
NFK79_RS21640 (4496103) 4496103..4496396 - 294 WP_096758750.1 type II toxin-antitoxin system CcdA family antitoxin -
NFK79_RS21645 (4496493) 4496493..4496858 - 366 WP_181498685.1 hypothetical protein -
NFK79_RS21650 (4496990) 4496990..4497163 + 174 WP_096758752.1 hypothetical protein -
NFK79_RS21655 (4497662) 4497662..4497940 + 279 WP_096758753.1 putative addiction module antidote protein -
NFK79_RS21660 (4497950) 4497950..4498267 - 318 WP_096758754.1 helix-turn-helix transcriptional regulator Antitoxin
NFK79_RS21665 (4498257) 4498257..4498616 - 360 WP_005132818.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFK79_RS21670 (4498830) 4498830..4499519 + 690 WP_096758755.1 dipeptidase PepE -
NFK79_RS21675 (4499648) 4499648..4501279 - 1632 WP_096758756.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(41-87)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13476.49 Da        Isoelectric Point: 10.3799

>T248199 WP_005132818.1 NZ_CP099084:c4498616-4498257 [Citrobacter freundii]
MTKPLYWVGHARKDLQGMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGNTWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEINLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11301.08 Da        Isoelectric Point: 4.7814

>AT248199 WP_096758754.1 NZ_CP099084:c4498267-4497950 [Citrobacter freundii]
MSHDVETSSGNVYADLGEYDAEQMQLKAQLAMVIGEILQCKGVTQQQAAEMLGMTQPKLSNLLRGQFRGISEAKMLECLV
KLGRDVAIVVGKEGDVPGTLKVSFG

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N6K5Y9

Antitoxin

Source ID Structure

References