Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4397069..4397604 Replicon chromosome
Accession NZ_CP099084
Organism Citrobacter freundii strain RHB43-C17

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NFK79_RS21215 Protein ID WP_096758666.1
Coordinates 4397317..4397604 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4BKM9
Locus tag NFK79_RS21210 Protein ID WP_006688247.1
Coordinates 4397069..4397320 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK79_RS21180 (4392139) 4392139..4392930 + 792 WP_137399228.1 alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ -
NFK79_RS21185 (4392927) 4392927..4393685 + 759 WP_096758661.1 phosphonate C-P lyase system protein PhnK -
NFK79_RS21190 (4393793) 4393793..4394473 + 681 WP_117343579.1 phosphonate C-P lyase system protein PhnL -
NFK79_RS21195 (4394470) 4394470..4395606 + 1137 WP_096758663.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
NFK79_RS21200 (4395609) 4395609..4396154 + 546 WP_096758664.1 ribose 1,5-bisphosphokinase -
NFK79_RS21205 (4396227) 4396227..4396985 + 759 WP_096758665.1 phosphonate metabolism protein PhnP -
NFK79_RS21210 (4397069) 4397069..4397320 + 252 WP_006688247.1 plasmid stabilization protein Antitoxin
NFK79_RS21215 (4397317) 4397317..4397604 + 288 WP_096758666.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFK79_RS21220 (4397601) 4397601..4397930 - 330 WP_096758667.1 DDRRRQL repeat protein YjdP -
NFK79_RS21225 (4397999) 4397999..4400263 - 2265 WP_279264510.1 hybrid sensor histidine kinase/response regulator -
NFK79_RS21230 (4400378) 4400378..4401901 + 1524 WP_279264511.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11092.00 Da        Isoelectric Point: 10.0828

>T248198 WP_096758666.1 NZ_CP099084:4397317-4397604 [Citrobacter freundii]
MSYTVKFREDALKEWQKLDKTIQQQFAKKLKKCCENPHVPSEKLGGIKDCYKIKLRTSGFRLVYQVIDETLVIAVVAVGK
RERSEVYNLASERLR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9215.53 Da        Isoelectric Point: 4.2965

>AT248198 WP_006688247.1 NZ_CP099084:4397069-4397320 [Citrobacter freundii]
MPHIILSDTTASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQQLVKLVHERSQQPLVDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7X1BT32

References