Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2517224..2517863 Replicon chromosome
Accession NZ_CP099084
Organism Citrobacter freundii strain RHB43-C17

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NFK79_RS12305 Protein ID WP_096756975.1
Coordinates 2517687..2517863 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NFK79_RS12300 Protein ID WP_137398867.1
Coordinates 2517224..2517640 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK79_RS12280 (2512267) 2512267..2513211 - 945 WP_096756980.1 ABC transporter permease -
NFK79_RS12285 (2513212) 2513212..2514228 - 1017 WP_096756979.1 ABC transporter ATP-binding protein -
NFK79_RS12290 (2514245) 2514245..2515390 - 1146 WP_117342825.1 ABC transporter substrate-binding protein -
NFK79_RS12295 (2515721) 2515721..2517130 - 1410 WP_096756977.1 PLP-dependent aminotransferase family protein -
NFK79_RS12300 (2517224) 2517224..2517640 - 417 WP_137398867.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFK79_RS12305 (2517687) 2517687..2517863 - 177 WP_096756975.1 type II toxin-antitoxin system HicA family toxin Toxin
NFK79_RS12310 (2518127) 2518127..2519530 + 1404 WP_181498226.1 cytochrome ubiquinol oxidase subunit I -
NFK79_RS12315 (2519530) 2519530..2520540 + 1011 WP_181498227.1 cytochrome d ubiquinol oxidase subunit II -
NFK79_RS12320 (2520540) 2520540..2520665 + 126 WP_096756972.1 DUF2474 domain-containing protein -
NFK79_RS12325 (2520852) 2520852..2521082 + 231 WP_096756971.1 DUF2554 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-68)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6737.76 Da        Isoelectric Point: 11.2510

>T248191 WP_096756975.1 NZ_CP099084:c2517863-2517687 [Citrobacter freundii]
VKQSEFRRWLESQGVDITHGSNHVKLRYQGRRSVMPRHPGDEIKEALRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15171.31 Da        Isoelectric Point: 4.4938

>AT248191 WP_137398867.1 NZ_CP099084:c2517640-2517224 [Citrobacter freundii]
MRYPVNLKPAVEGGFVVSFPDIPEALTQGDSRHEALEAAQDALVTAFEFYFDDNETIPLPSAVDAADDYVEIPLSVASKV
LLLNTFLEAKITQQELASRIGRPKQEITRLFDLKHATKIDAVQAAVRALGKQLSLTMQ

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References