24819

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2017504..2019140 Replicon chromosome
Accession NC_014259
Organism Acinetobacter oleivorans DR1

Toxin (Protein)


Gene name hipA Uniprot ID D8JJV1
Locus tag AOLE_RS09485 Protein ID WP_013197855.1
Coordinates 2017504..2018835 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag AOLE_RS09490 Protein ID WP_035331573.1
Coordinates 2018832..2019140 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOLE_RS20375 2013611..2013763 - 153 WP_013197851.1 hypothetical protein -
AOLE_RS09470 2013981..2014919 + 939 WP_013197852.1 hydroxymethylglutaryl-CoA lyase -
AOLE_RS09475 2014921..2016114 + 1194 WP_013197853.1 CoA transferase -
AOLE_RS09480 2016263..2017258 - 996 WP_013197854.1 putative multidrug efflux protein AdeT1 -
AOLE_RS09485 2017504..2018835 + 1332 WP_013197855.1 HipA domain-containing protein Toxin
AOLE_RS09490 2018832..2019140 + 309 WP_035331573.1 helix-turn-helix domain-containing protein Antitoxin
AOLE_RS09495 2019223..2019987 - 765 WP_013197857.1 isochorismatase family protein -
AOLE_RS09500 2020078..2020677 - 600 WP_013197858.1 prolyl oligopeptidase family serine peptidase -
AOLE_RS09505 2020753..2021157 - 405 WP_005305413.1 DoxX family protein -
AOLE_RS09510 2021261..2022154 - 894 WP_013197859.1 LysR family transcriptional regulator -
AOLE_RS09515 2022284..2023354 - 1071 WP_013197860.1 two-component sensor histidine kinase AdeS -
AOLE_RS09520 2023387..2024130 - 744 WP_013197861.1 efflux system response regulator transcription factor AdeR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-357)

Antitoxin

Cro/C1-type helix-turn-helix domain

(29-82)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 50912.72 Da        Isoelectric Point: 5.0412

>T24819 WP_013197855.1 NC_014259:2017504-2018835 [Acinetobacter oleivorans DR1]
MKKLTIQALLDTNWLDIAELKLLESKQGSASASELEYELDYALQYLDKRDEHACSLSLPVQILIKHESSTWFGFLDDIVP
SGAARRYWVNYLDLQRLTHAEQDSILLEKGGIAPVGNLRIKEALPPINPDSTLHLRYFSKEDVADRNVDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPDQKVWIDTYQENFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFDTIETTQM
KLIEGTKYPSLWLPRFDTEWRNQQWHRHGLESVYSVLNKSSGSHLNHFEVIENLCNLLTHIDSDFDASQFICEWLQRDLL
NIIFGNSDNHGRNTSFLKKSGKISLSPIYDFAPMKADPEVVIRSTTWGSPYEEGGEYRWVQITQKLAPWCDPDLSIGALK
SLARNFVGLKQRLIDKGVPQQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

>T24819 NC_014259:2017504-2018835 [Acinetobacter oleivorans DR1]
ATGAAAAAATTAACGATACAAGCACTACTTGATACGAACTGGTTAGATATAGCAGAACTAAAACTGTTAGAGTCTAAACA
AGGTTCGGCTAGTGCAAGTGAATTAGAGTATGAATTGGATTATGCGCTTCAATATTTAGACAAGCGCGATGAGCACGCCT
GTAGTTTGTCACTTCCTGTGCAAATACTTATAAAACATGAATCGAGCACATGGTTTGGTTTTTTAGATGATATCGTTCCT
TCAGGTGCTGCACGACGTTACTGGGTGAATTATCTAGATTTACAACGTTTAACTCATGCAGAGCAAGATAGTATCTTATT
AGAAAAAGGGGGCATTGCTCCTGTTGGTAATTTACGGATTAAAGAAGCACTTCCACCTATAAATCCTGACTCAACTTTAC
ACTTACGTTATTTCAGTAAAGAAGATGTGGCTGATCGTAATGTTGATTTTCTTGAGTACGCTCAGCAAATGGGTGCGATT
AGTGGTGGTGCAACTGGTGCCGGTGGAGAAGCGCCCAAATTACTTATTCGTGTTTCGCCAGATCAAAAAGTCTGGATTGA
TACATACCAAGAAAATTTTGATCAACCAGATCAACATTATTTAGTTAAATTTCCAAGAAATAAGCGCAGTGAAATTGATT
GCGACATTCTCAGAGCTGAATATTATTACTATCAAATACTCAATGAATTAGGTTTTGATACGATTGAGACAACTCAAATG
AAGCTCATTGAAGGTACAAAGTATCCTTCTTTATGGCTGCCAAGATTTGACACAGAATGGCGTAATCAGCAGTGGCACCG
TCATGGTTTGGAATCTGTTTATTCGGTACTAAATAAGTCTTCAGGTAGTCATCTTAATCATTTTGAAGTTATAGAGAATC
TATGCAATTTACTGACTCACATCGATTCAGATTTTGATGCTTCACAATTCATCTGTGAGTGGTTACAAAGAGATTTGCTT
AATATTATTTTCGGTAATTCAGACAATCATGGTCGTAATACATCTTTTCTAAAAAAATCAGGAAAAATTTCTCTTTCTCC
TATTTATGATTTTGCGCCTATGAAAGCCGATCCAGAAGTAGTGATTAGATCGACTACATGGGGAAGTCCGTATGAAGAAG
GCGGTGAGTATCGTTGGGTTCAAATTACCCAAAAACTTGCACCTTGGTGTGACCCAGATTTGTCTATAGGCGCATTAAAA
TCACTGGCACGTAATTTTGTTGGACTAAAACAACGCTTAATCGATAAAGGTGTACCTCAACAGATTATTGAAATGCCAGC
ACTTTCATTTGACTACATAGAAGCTAAATTGAAAAGATGGGAGCTGTTATAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11637.58 Da        Isoelectric Point: 9.9701

>AT24819 WP_035331573.1 NC_014259:2018832-2019140 [Acinetobacter oleivorans DR1]
INMKNQTQDRQQVLIDLYKQYLFNEITLGQLLTYLRKNVLSLSQEQYAALVGVSRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVGKIIKLSE

Download         Length: 309 bp

>AT24819 NC_014259:2018832-2019140 [Acinetobacter oleivorans DR1]
ATAAACATGAAAAATCAGACTCAAGATCGTCAGCAAGTTCTCATCGATTTATATAAACAATATTTATTTAATGAAATTAC
GCTTGGTCAATTGTTGACGTATTTGCGAAAGAACGTATTGAGCTTGTCTCAAGAGCAATATGCTGCTTTGGTTGGAGTAA
GTCGTCGAACATTAACTGATATTGAGCAGGATAAAGGTAAACTTACCCAATCTGTGTTAGATAAGGTGTTTAAGCCGCTG
GGTTTAAAAGCAGGGCTTGTACCTACACATGAACATATTGTTGGTAAAATTATCAAACTGTCCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D8JJV1

Antitoxin

Source ID Structure

References