Detailed information of TA system TA024819

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2017504..2019140
• Replicon: chromosome
• Accession: NC_014259
• Organism: Acinetobacter oleivorans DR1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: D8JJV1
• Locus tag: AOLE_RS09485
• Protein ID: WP_013197855.1
• Coordinates: 2017504..2018835 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: AOLE_RS09490
• Protein ID: WP_035331573.1
• Coordinates: 2018832..2019140 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOLE_RS20375	2013611..2013763	-	153	WP_013197851.1	hypothetical protein	-
AOLE_RS09470	2013981..2014919	+	939	WP_013197852.1	hydroxymethylglutaryl-CoA lyase	-
AOLE_RS09475	2014921..2016114	+	1194	WP_013197853.1	CoA transferase	-
AOLE_RS09480	2016263..2017258	-	996	WP_013197854.1	putative multidrug efflux protein AdeT1	-
AOLE_RS09485	2017504..2018835	+	1332	WP_013197855.1	HipA domain-containing protein	Toxin
AOLE_RS09490	2018832..2019140	+	309	WP_035331573.1	helix-turn-helix domain-containing protein	Antitoxin
AOLE_RS09495	2019223..2019987	-	765	WP_013197857.1	isochorismatase family protein	-
AOLE_RS09500	2020078..2020677	-	600	WP_013197858.1	prolyl oligopeptidase family serine peptidase	-
AOLE_RS09505	2020753..2021157	-	405	WP_005305413.1	DoxX family protein	-
AOLE_RS09510	2021261..2022154	-	894	WP_013197859.1	LysR family transcriptional regulator	-
AOLE_RS09515	2022284..2023354	-	1071	WP_013197860.1	two-component sensor histidine kinase AdeS	-
AOLE_RS09520	2023387..2024130	-	744	WP_013197861.1	efflux system response regulator transcription factor AdeR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-357)

Antitoxin

• Cro/C1-type helix-turn-helix domain (29-82)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 50912.72 Da
• Isoelectric Point: 5.0412

>T24819 WP_013197855.1 NC_014259:2017504-2018835 [Acinetobacter oleivorans DR1]
MKKLTIQALLDTNWLDIAELKLLESKQGSASASELEYELDYALQYLDKRDEHACSLSLPVQILIKHESSTWFGFLDDIVP
SGAARRYWVNYLDLQRLTHAEQDSILLEKGGIAPVGNLRIKEALPPINPDSTLHLRYFSKEDVADRNVDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPDQKVWIDTYQENFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFDTIETTQM
KLIEGTKYPSLWLPRFDTEWRNQQWHRHGLESVYSVLNKSSGSHLNHFEVIENLCNLLTHIDSDFDASQFICEWLQRDLL
NIIFGNSDNHGRNTSFLKKSGKISLSPIYDFAPMKADPEVVIRSTTWGSPYEEGGEYRWVQITQKLAPWCDPDLSIGALK
SLARNFVGLKQRLIDKGVPQQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T24819 NC_014259:2017504-2018835 [Acinetobacter oleivorans DR1]
ATGAAAAAATTAACGATACAAGCACTACTTGATACGAACTGGTTAGATATAGCAGAACTAAAACTGTTAGAGTCTAAACA
AGGTTCGGCTAGTGCAAGTGAATTAGAGTATGAATTGGATTATGCGCTTCAATATTTAGACAAGCGCGATGAGCACGCCT
GTAGTTTGTCACTTCCTGTGCAAATACTTATAAAACATGAATCGAGCACATGGTTTGGTTTTTTAGATGATATCGTTCCT
TCAGGTGCTGCACGACGTTACTGGGTGAATTATCTAGATTTACAACGTTTAACTCATGCAGAGCAAGATAGTATCTTATT
AGAAAAAGGGGGCATTGCTCCTGTTGGTAATTTACGGATTAAAGAAGCACTTCCACCTATAAATCCTGACTCAACTTTAC
ACTTACGTTATTTCAGTAAAGAAGATGTGGCTGATCGTAATGTTGATTTTCTTGAGTACGCTCAGCAAATGGGTGCGATT
AGTGGTGGTGCAACTGGTGCCGGTGGAGAAGCGCCCAAATTACTTATTCGTGTTTCGCCAGATCAAAAAGTCTGGATTGA
TACATACCAAGAAAATTTTGATCAACCAGATCAACATTATTTAGTTAAATTTCCAAGAAATAAGCGCAGTGAAATTGATT
GCGACATTCTCAGAGCTGAATATTATTACTATCAAATACTCAATGAATTAGGTTTTGATACGATTGAGACAACTCAAATG
AAGCTCATTGAAGGTACAAAGTATCCTTCTTTATGGCTGCCAAGATTTGACACAGAATGGCGTAATCAGCAGTGGCACCG
TCATGGTTTGGAATCTGTTTATTCGGTACTAAATAAGTCTTCAGGTAGTCATCTTAATCATTTTGAAGTTATAGAGAATC
TATGCAATTTACTGACTCACATCGATTCAGATTTTGATGCTTCACAATTCATCTGTGAGTGGTTACAAAGAGATTTGCTT
AATATTATTTTCGGTAATTCAGACAATCATGGTCGTAATACATCTTTTCTAAAAAAATCAGGAAAAATTTCTCTTTCTCC
TATTTATGATTTTGCGCCTATGAAAGCCGATCCAGAAGTAGTGATTAGATCGACTACATGGGGAAGTCCGTATGAAGAAG
GCGGTGAGTATCGTTGGGTTCAAATTACCCAAAAACTTGCACCTTGGTGTGACCCAGATTTGTCTATAGGCGCATTAAAA
TCACTGGCACGTAATTTTGTTGGACTAAAACAACGCTTAATCGATAAAGGTGTACCTCAACAGATTATTGAAATGCCAGC
ACTTTCATTTGACTACATAGAAGCTAAATTGAAAAGATGGGAGCTGTTATAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11637.58 Da
• Isoelectric Point: 9.9701

>AT24819 WP_035331573.1 NC_014259:2018832-2019140 [Acinetobacter oleivorans DR1]
INMKNQTQDRQQVLIDLYKQYLFNEITLGQLLTYLRKNVLSLSQEQYAALVGVSRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVGKIIKLSE

Nucleotide

• Length: 309 bp

>AT24819 NC_014259:2018832-2019140 [Acinetobacter oleivorans DR1]
ATAAACATGAAAAATCAGACTCAAGATCGTCAGCAAGTTCTCATCGATTTATATAAACAATATTTATTTAATGAAATTAC
GCTTGGTCAATTGTTGACGTATTTGCGAAAGAACGTATTGAGCTTGTCTCAAGAGCAATATGCTGCTTTGGTTGGAGTAA
GTCGTCGAACATTAACTGATATTGAGCAGGATAAAGGTAAACTTACCCAATCTGTGTTAGATAAGGTGTTTAAGCCGCTG
GGTTTAAAAGCAGGGCTTGTACCTACACATGAACATATTGTTGGTAAAATTATCAAACTGTCCGAGTAG

Structures

Toxin

• AlphaFold DB: D8JJV1