248189

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2259908..2260434 Replicon chromosome
Accession NZ_CP099084
Organism Citrobacter freundii strain RHB43-C17

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag NFK79_RS11060 Protein ID WP_000323025.1
Coordinates 2260147..2260434 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag NFK79_RS11055 Protein ID WP_000534858.1
Coordinates 2259908..2260147 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK79_RS11030 (2254908) 2254908..2255789 + 882 WP_279264806.1 dsDNA nuclease domain-containing protein -
NFK79_RS11035 (2255789) 2255789..2257441 + 1653 WP_001575467.1 hypothetical protein -
NFK79_RS11040 (2258038) 2258038..2258478 + 441 WP_279264781.1 hypothetical protein -
NFK79_RS11045 (2258754) 2258754..2259506 - 753 WP_279264782.1 hypothetical protein -
NFK79_RS11050 (2259779) 2259779..2259883 - 105 Protein_2161 protein YdfV -
NFK79_RS11055 (2259908) 2259908..2260147 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
NFK79_RS11060 (2260147) 2260147..2260434 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
NFK79_RS11065 (2260491) 2260491..2261414 + 924 Protein_2164 aldehyde dehydrogenase family protein -
NFK79_RS11070 (2261426) 2261426..2261899 + 474 WP_181499357.1 ester cyclase -
NFK79_RS11075 (2261982) 2261982..2263874 + 1893 WP_181499358.1 NAD(P)/FAD-dependent oxidoreductase -
NFK79_RS11080 (2263878) 2263878..2265089 + 1212 WP_096757185.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2246342..2260434 14092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T248189 WP_000323025.1 NZ_CP099084:2260147-2260434 [Citrobacter freundii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT248189 WP_000534858.1 NZ_CP099084:2259908-2260147 [Citrobacter freundii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References