Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1317721..1318460 Replicon chromosome
Accession NZ_CP099084
Organism Citrobacter freundii strain RHB43-C17

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag NFK79_RS06295 Protein ID WP_096757948.1
Coordinates 1317975..1318460 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag NFK79_RS06290 Protein ID WP_096757949.1
Coordinates 1317721..1317987 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK79_RS06260 (1312877) 1312877..1314121 - 1245 WP_096757955.1 mechanosensitive ion channel family protein -
NFK79_RS06265 (1314186) 1314186..1314839 - 654 WP_096757954.1 oxygen-insensitive NAD(P)H nitroreductase -
NFK79_RS06270 (1314959) 1314959..1315327 - 369 WP_181499086.1 MmcQ/YjbR family DNA-binding protein -
NFK79_RS06275 (1315327) 1315327..1315908 - 582 WP_096757952.1 TetR/AcrR family transcriptional regulator -
NFK79_RS06280 (1316098) 1316098..1317195 + 1098 WP_181499088.1 MBL fold metallo-hydrolase -
NFK79_RS06285 (1317224) 1317224..1317565 + 342 WP_096757950.1 RamA family antibiotic efflux transcriptional regulator -
NFK79_RS06290 (1317721) 1317721..1317987 + 267 WP_096757949.1 DUF1778 domain-containing protein Antitoxin
NFK79_RS06295 (1317975) 1317975..1318460 + 486 WP_096757948.1 GNAT family N-acetyltransferase Toxin
NFK79_RS06300 (1318734) 1318734..1318982 - 249 WP_096757947.1 DUF1158 family protein -
NFK79_RS06305 (1319049) 1319049..1320167 - 1119 WP_096757946.1 YbdK family carboxylate-amine ligase -
NFK79_RS06310 (1320435) 1320435..1321139 + 705 WP_096757944.1 GNAT family protein -
NFK79_RS06315 (1321223) 1321223..1322302 + 1080 WP_181499089.1 alpha/beta hydrolase -
NFK79_RS06320 (1322292) 1322292..1322945 - 654 WP_096757942.1 enterobactin synthase subunit EntD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(28-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17732.53 Da        Isoelectric Point: 10.0703

>T248188 WP_096757948.1 NZ_CP099084:1317975-1318460 [Citrobacter freundii]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQIAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVELSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLKLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10104.52 Da        Isoelectric Point: 4.3952

>AT248188 WP_096757949.1 NZ_CP099084:1317721-1317987 [Citrobacter freundii]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILERRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References