248187

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1206975..1207595 Replicon chromosome
Accession NZ_CP099084
Organism Citrobacter freundii strain RHB43-C17

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFK79_RS05770 Protein ID WP_002892050.1
Coordinates 1206975..1207193 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag NFK79_RS05775 Protein ID WP_096758040.1
Coordinates 1207221..1207595 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK79_RS05740 (1202914) 1202914..1203525 + 612 WP_181499051.1 hypothetical protein -
NFK79_RS05745 (1203608) 1203608..1203961 + 354 WP_115259217.1 DUF1428 family protein -
NFK79_RS05750 (1204015) 1204015..1205568 - 1554 WP_096758043.1 EAL domain-containing protein -
NFK79_RS05755 (1205753) 1205753..1206013 + 261 WP_096758042.1 type B 50S ribosomal protein L31 -
NFK79_RS05760 (1206015) 1206015..1206155 + 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFK79_RS05765 (1206229) 1206229..1206702 - 474 WP_096758041.1 YlaC family protein -
NFK79_RS05770 (1206975) 1206975..1207193 - 219 WP_002892050.1 HHA domain-containing protein Toxin
NFK79_RS05775 (1207221) 1207221..1207595 - 375 WP_096758040.1 Hha toxicity modulator TomB Antitoxin
NFK79_RS05780 (1208084) 1208084..1211233 - 3150 WP_096758039.1 efflux RND transporter permease AcrB -
NFK79_RS05785 (1211256) 1211256..1212449 - 1194 WP_096758038.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248187 WP_002892050.1 NZ_CP099084:c1207193-1206975 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT248187 WP_096758040.1 NZ_CP099084:c1207595-1207221 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSNYGINTQDLQKWRKSGSRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure

References