Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 458164..458942 Replicon chromosome
Accession NZ_CP099084
Organism Citrobacter freundii strain RHB43-C17

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag NFK79_RS02240 Protein ID WP_279264552.1
Coordinates 458454..458942 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag NFK79_RS02235 Protein ID WP_096758633.1
Coordinates 458164..458457 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK79_RS02230 (454236) 454236..457496 + 3261 WP_279264551.1 peroxidase family protein -
NFK79_RS02235 (458164) 458164..458457 + 294 WP_096758633.1 DUF1778 domain-containing protein Antitoxin
NFK79_RS02240 (458454) 458454..458942 + 489 WP_279264552.1 GNAT family N-acetyltransferase Toxin
NFK79_RS02245 (459227) 459227..459406 - 180 Protein_440 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
NFK79_RS02250 (460374) 460374..461714 - 1341 WP_279264553.1 hypothetical protein -
NFK79_RS02255 (461792) 461792..462685 - 894 Protein_442 IS3 family transposase -
NFK79_RS02260 (462698) 462698..463849 - 1152 WP_112150722.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 458164..470557 12393


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17587.57 Da        Isoelectric Point: 7.7294

>T248185 WP_279264552.1 NZ_CP099084:458454-458942 [Citrobacter freundii]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQLSGASRTFVCCDDVKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGQGLGRALMRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPLMLMVTLGDLVG
SV

Download         Length: 489 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10932.58 Da        Isoelectric Point: 9.8590

>AT248185 WP_096758633.1 NZ_CP099084:458164-458457 [Citrobacter freundii]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLTRLDQAPAPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References