248182

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4326098..4326801 Replicon chromosome
Accession NZ_CP099037
Organism Citrobacter freundii strain RHB44-SO-C05

Toxin (Protein)


Gene name ypjF Uniprot ID A0A0L0H2I3
Locus tag NFL15_RS20885 Protein ID WP_021530985.1
Coordinates 4326098..4326439 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag NFL15_RS20890 Protein ID WP_126026844.1
Coordinates 4326460..4326801 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL15_RS20865 (4321123) 4321123..4322493 - 1371 WP_003837154.1 tyrosine phenol-lyase -
NFL15_RS20870 (4323272) 4323272..4323634 + 363 WP_048219798.1 endoribonuclease SymE -
NFL15_RS20875 (4323787) 4323787..4324659 + 873 WP_081366016.1 HNH endonuclease -
NFL15_RS20880 (4324840) 4324840..4325847 - 1008 WP_004108748.1 restriction endonuclease -
NFL15_RS20885 (4326098) 4326098..4326439 - 342 WP_021530985.1 TA system toxin CbtA family protein Toxin
NFL15_RS20890 (4326460) 4326460..4326801 - 342 WP_126026844.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NFL15_RS20895 (4326812) 4326812..4327354 - 543 WP_126026845.1 DNA repair protein RadC -
NFL15_RS20900 (4327367) 4327367..4327807 - 441 WP_126026846.1 antirestriction protein -
NFL15_RS20905 (4327838) 4327838..4328659 - 822 WP_126026847.1 DUF932 domain-containing protein -
NFL15_RS20910 (4328780) 4328780..4329253 - 474 WP_126026848.1 hypothetical protein -
NFL15_RS20915 (4329325) 4329325..4329777 - 453 WP_031280325.1 hypothetical protein -
NFL15_RS20920 (4329813) 4329813..4330529 - 717 WP_001757887.1 WYL domain-containing protein -
NFL15_RS20925 (4330773) 4330773..4331648 - 876 WP_126026849.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(13-111)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12838.71 Da        Isoelectric Point: 6.4789

>T248182 WP_021530985.1 NZ_CP099037:c4326439-4326098 [Citrobacter freundii]
MKTLPATNPQAAKLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKARHGEHWE

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12724.40 Da        Isoelectric Point: 6.7345

>AT248182 WP_126026844.1 NZ_CP099037:c4326801-4326460 [Citrobacter freundii]
MKSTDSENDSFLKWGLNRNVIPCFGARLVQEGNRLHYLADRASITGKFSEAECLKLDVAFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYSTHR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L0H2I3

Antitoxin

Source ID Structure

References