Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3679748..3680368 Replicon chromosome
Accession NZ_CP099037
Organism Citrobacter freundii strain RHB44-SO-C05

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFL15_RS17920 Protein ID WP_002892050.1
Coordinates 3680150..3680368 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag NFL15_RS17915 Protein ID WP_003021733.1
Coordinates 3679748..3680122 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL15_RS17905 (3674894) 3674894..3676087 + 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFL15_RS17910 (3676110) 3676110..3679259 + 3150 WP_003021736.1 efflux RND transporter permease AcrB -
NFL15_RS17915 (3679748) 3679748..3680122 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
NFL15_RS17920 (3680150) 3680150..3680368 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFL15_RS17925 (3680550) 3680550..3681101 + 552 WP_138828274.1 maltose O-acetyltransferase -
NFL15_RS17930 (3681218) 3681218..3681688 + 471 WP_003021724.1 YlaC family protein -
NFL15_RS17935 (3681766) 3681766..3681906 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFL15_RS17940 (3681908) 3681908..3682168 - 261 WP_003021719.1 type B 50S ribosomal protein L31 -
NFL15_RS17945 (3682357) 3682357..3683910 + 1554 WP_003835927.1 EAL domain-containing protein -
NFL15_RS17950 (3683962) 3683962..3684315 - 354 WP_003831033.1 DUF1428 family protein -
NFL15_RS17955 (3684380) 3684380..3685009 - 630 WP_016149709.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248181 WP_002892050.1 NZ_CP099037:3680150-3680368 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT248181 WP_003021733.1 NZ_CP099037:3679748-3680122 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References