Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 874862..875523 Replicon chromosome
Accession NZ_CP099037
Organism Citrobacter freundii strain RHB44-SO-C05

Toxin (Protein)


Gene name ypjF Uniprot ID S3IMJ6
Locus tag NFL15_RS04320 Protein ID WP_000698542.1
Coordinates 875200..875523 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID S3J179
Locus tag NFL15_RS04315 Protein ID WP_000065326.1
Coordinates 874862..875179 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL15_RS04270 (870002) 870002..870826 + 825 WP_000197385.1 DUF932 domain-containing protein -
NFL15_RS04275 (871035) 871035..871745 + 711 WP_024198336.1 hypothetical protein -
NFL15_RS04280 (871771) 871771..872307 + 537 WP_000219797.1 DUF4339 domain-containing protein -
NFL15_RS04285 (872349) 872349..872786 + 438 WP_024198335.1 hypothetical protein -
NFL15_RS04290 (872853) 872853..873263 + 411 WP_000912997.1 hypothetical protein -
NFL15_RS04295 (873341) 873341..873577 + 237 WP_000004273.1 DUF905 domain-containing protein -
NFL15_RS04300 (873663) 873663..874121 + 459 WP_016538084.1 antirestriction protein -
NFL15_RS04305 (874137) 874137..874613 + 477 WP_000811694.1 RadC family protein -
NFL15_RS04310 (874622) 874622..874843 + 222 WP_000691995.1 DUF987 domain-containing protein -
NFL15_RS04315 (874862) 874862..875179 + 318 WP_000065326.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NFL15_RS04320 (875200) 875200..875523 + 324 WP_000698542.1 TA system toxin CbtA family protein Toxin
NFL15_RS04325 (875764) 875764..876300 - 537 WP_003033852.1 GNAT family N-acetyltransferase -
NFL15_RS04330 (877117) 877117..879579 + 2463 WP_202581010.1 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12350.38 Da        Isoelectric Point: 8.9789

>T248175 WP_000698542.1 NZ_CP099037:875200-875523 [Citrobacter freundii]
MKILPATISRAAKPCLPPVAVWQLLLTRLLEKHYGLTLNDTPFSDETVIKEHFDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTPYLTNIDIMRARRDLGLLNRN

Download         Length: 324 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11830.50 Da        Isoelectric Point: 6.9367

>AT248175 WP_000065326.1 NZ_CP099037:874862-875179 [Citrobacter freundii]
MSNIIWGLQRDITPRLGTRLVQEGNQLHYLADRACITGKFSDAECLKLDVAFPHFISRMESMLSTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYVAVYSTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3IMJ6

Antitoxin

Source ID Structure
AlphaFold DB S3J179

References