Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4446921..4447702 Replicon chromosome
Accession NZ_CP098834
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain GD19PS1

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag NFH28_RS21955 Protein ID WP_000626099.1
Coordinates 4446921..4447412 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NFH28_RS21960 Protein ID WP_001110452.1
Coordinates 4447409..4447702 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFH28_RS21915 (4442107) 4442107..4442349 - 243 WP_197603740.1 hypothetical protein -
NFH28_RS21920 (4442346) 4442346..4442702 - 357 WP_033567083.1 hypothetical protein -
NFH28_RS21925 (4442699) 4442699..4443571 - 873 WP_033567082.1 ParA family protein -
NFH28_RS21930 (4443762) 4443762..4443839 - 78 Protein_4298 helix-turn-helix domain-containing protein -
NFH28_RS21935 (4443930) 4443930..4444262 - 333 WP_001165471.1 MerR family transcriptional regulator -
NFH28_RS21940 (4444334) 4444334..4444711 + 378 WP_000916345.1 EthD family reductase -
NFH28_RS21945 (4445744) 4445744..4445818 + 75 Protein_4301 porin family protein -
NFH28_RS21950 (4445921) 4445921..4446673 + 753 WP_000842434.1 non-specific acid phosphatase -
NFH28_RS21955 (4446921) 4446921..4447412 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
NFH28_RS21960 (4447409) 4447409..4447702 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NFH28_RS21965 (4448019) 4448019..4448240 + 222 WP_001576552.1 hypothetical protein -
NFH28_RS21970 (4448505) 4448505..4449380 + 876 WP_000921674.1 AraC family transcriptional regulator -
NFH28_RS21975 (4449377) 4449377..4449664 + 288 WP_001269916.1 transcriptional regulator RtsB -
NFH28_RS21980 (4449687) 4449687..4449902 + 216 WP_001595136.1 hypothetical protein -
NFH28_RS21985 (4449910) 4449910..4450179 + 270 WP_010989096.1 hypothetical protein -
NFH28_RS21990 (4450473) 4450473..4451378 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T248162 WP_000626099.1 NZ_CP098834:c4447412-4446921 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT248162 WP_001110452.1 NZ_CP098834:c4447702-4447409 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References